Classic Labs/Findings III Flashcards
Low serum ceruloplasmin
Wilson disease (hepatolenticular degenration)
“Lumpy bumpy” appearance of glomeruli on immunofluorescence
Poststreptococcal glomerulonephritis (due to deposition of IgG, IgM, and C3)
Lytic (“punched out”) bone lesions on x-ray
Multiple myeloma
Mammary gland (“blue domed”) cyst
Fibrocystic change of the breast
Monoclonal antibody spike
Multiple myeloma (usually IgG or IgA) Monoclonal gammopathy of undetermined significance (consequence of aging) Waldenstrom (M protein = IgM) macroglobulinemia Primary amyloidosis
Mucin-filled cell with peripheral nucleus
“Signet ring” (gastric carcinoma)
Narrowing of bowel lumen on barium X-ray
“String sign” (Crohn’s disease)
Nodular hyaline deposits in glomeruli
Kimmelsteil-Wilson nodules (diabetic nephropathy)
Necrotizing vasculitis (lungs) and necrotising glomerulonephritis
Granulomatous with polyangiitis (Wegener, Pr3-ANCA and c-ANCA) Goodpasture syndrome (anti-basement membrane antibodies)
Needle-shaped, negatively birefringent crystals
Gout (monosodium urate crystals)
Novobiocin response
Sensitive: Staph epidermidis
Resistant: Staph saprophyticus
Nutmeg appearance of liver
Chronic passive congestion of liver due to right heart failure or Budd Chiari syndrome
Optochin response
Sensitive: Strep pneumoniae
Resistant: Strep viridans (mutans, sanguis)
Onion skin periosteal reaction
Ewing sarcoma (malignant small blue cell tumor)
Periosteum raised from bone, creating triangular area
Codman triangle on x-ray, Ewing sarcoma, pyogenic osteomyelitis