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Classic Labs/Findings Flashcards

1
Q

Anticentromere Ab

A

Scleroderma (CREST)

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2
Q

Anti-desmoglein (anti-desmosome) Ab

A

Pemphigus vulgaris (blistering)

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3
Q

Anti-glomerular basement membrane Ab

A

Goodpasture syndrome (glomerulonephritis and hemoptysis)

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4
Q

Antihistone Ab

A

Drug-induced SLE (eg hydra lazing, isoniazid, phenytoin, procainamide)

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5
Q

Anti-IgG Ab

A

Rheumatoid arthritis (systemic inflammation, joint pan us, boutonniere deformity)

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6
Q

Antimitochondrial Ab (AMAs)

A

Primary Biliary Cirrhosis (female, cholestasis, portal HTN)

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7
Q

Antineutrophil cytoplasmic Ab (ANCAs)

A

Microscopic polyangitis and eosinophilic granulomatosis with polyangitis (Churg-Strauss syndrome)-MPO-ANCA/p-ANCA
Granulomatosis with polyangitis (Wegeners)-PR3-ANCA/c-ANCA

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8
Q

Antinuclear Ab (ANAs: anti-smith and anti-dsDNA)

A

SLE (type III hypersensitivity)

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9
Q

Antiplatelet Ab

A

Idiopathic thrombocytopenic purpura

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10
Q

Anti-topoisomerase Ab

A

Diffuse systemic scleroderma

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11
Q

Anti-transglutaminase/anti-gliadin/anti-endomysial Ab

A

Celiac disease (diarrhea, weight loss)

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12
Q

“Apple core” lesion on barium enema X-Ray

A

Colorectal cancer (usually left sided)

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13
Q

Atypical lymphocytes

A

EBV

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14
Q

Azurophilic peroxidase positive granular inclusions in granulocytes and myeloblasts

A

Auer rods (AML, esp the promyelocytic [M3] type)

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15
Q

Bacitracin response

A

Sensitive: S.pyogenes (group A)
Resistant: S.agalactiae (group B)

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16
Q

Bamboo spine on XR

A

Ankylosis get spondylitis (chronic inflammatory arthritis, HLA-B27)

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17
Q

Basophilic nuclear remnants in RBCs

A

Howell-Jolly bodies (due to splenectomy or nonfunctional spleen)

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18
Q

Basophils can stippling of RBCs

A

Lead poisoning or sideroblastic anemia

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19
Q

Bloody or yellow tap on lumbar puncture

A

Subarachnoid hemorrhage

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20
Q

Boot-shaped heart on XR

A

Tetralogy of Fallot (due to RVH)

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21
Q

Branching gram + rods with sulfur granules

A

Actinomyces israelii

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22
Q

Bronchogenic apical lung tumor on imaging

A

Pancoast tumor (can compress cervical sympathetic chain and cause Horner syndrome)

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23
Q

“Brown” tumor of the bone

A

Hyperparathyroidism or osteitis Fibrosa cystica (deposited hemosiderin from hemorrhage gives brown color)

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24
Q

Cardiomegaly with apical atrophy

A

Chagas’ disease (Trypanosoma cruzi)

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25
Q

Cellular crescents in Bowman Capsule

A

Rapidly progressive crescentic glomerulonephritis

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26
Q

Chocolate cyst of ovary

A

Endometriosis (frequently) involves both ovaries

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27
Q

Circular grouping of dark tumor cells surrounding pale neurofibrils

A

Homer-Wright rosettes (neuroblastoma, medulloblastoma)

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28
Q

Colonies of mucoid Pseudomonas in lungs

A

Cystic fibrosis (AR mutation in CFTR gene –> fat soluble vitamin deficiency and mucous plugs)

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29
Q

decrease in AFP in amniotic fluids/maternal serum

A

Down syndrome and other chromosomal anomalies

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30
Q

Degeneration of dorsal column fibers

A

Tabes dorsalis (tertiary syphilis), subacute combined degeneration (dorsal columns, lateral corticospinal, spinocerebellar tracts affected)

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31
Q

“Delta wave” on EKG, short PR interval, supraventricular tachycardia

A

Wolf-Parkinson-White syndrome (bundle of Kent bypasses AV node)

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32
Q

Depigmentation of neurons in substantia nigra

A

Parkinson disease (basal ganglia disorder; rigidity, resting tremor, bradykinesia)

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33
Q

Desquamated epithelium casts in sputum

A

Curschmann spirals (bronchial asthma; can result in whorled mucous plugs)

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34
Q

Disarray end granulosa cells arranged around collections of eosinophilic fluid

A

Call-Exner bodies (granulosa cell tumor of the ovary)

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35
Q

Dysplasia squamous cervical cells with “raisinoid” nuclei and hyperchromasia

A

Koilocytes (HPV: predisposes to cervical cancer)

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36
Q

Electrical alternans (alternating amplitude on EKG)

A

Pericardial tamponade

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37
Q

Enlarged cells with intranuclear inclusion bodies

A

“Owl eye” appearance of CMV

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38
Q

Enlarged thyroid cells with ground-glass nuclei with central clearing

A

“Orphan Annie” eye nuclei (papillary carcinoma of the thyroid)

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39
Q

Eosinophilic cytoplasmic inclusion in liver cell

A

Mallory body (alcoholic liver disease)

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40
Q

Eosinophilic cytoplasmic inclusion in neuron

A

Lewy body (Parkinson disease and Lewy body dementia)

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41
Q

Eosinophilic globule in liver

A

Councilman body (viral hepatitis, yellow fever), represents hepatocytes undergoing apoptosis

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42
Q

Eosinophilic inclusion bodies in cytoplasm of hippocampal and cerebellar neurons

A

Negri bodies of rabies

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43
Q

Extracellular amyloid deposition in gray matter of brain

A

Senile plaques (ALZ disease)

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44
Q

Giant B cells with beloved nuclei with prominent inclusions (owl’s eyes)

A

Reed-Sternberg cells (Hodgkin lymphoma)

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45
Q

Glomerulus-like structure surrounding vessel in germ cells

A

Schiller-Duval bodies (yolk sac tumor)

46
Q

“Hair on end” Crew cut appearance on XR

A

beta-thalassemia, sickle cell disease (marrow expansion)

47
Q

Increased AFP in amniotic fluid/maternal serum

A

Dating error, anencephaly, spina bifida (neural tube defects)

48
Q

HCG elevated

A

Choriocarcinoma, hydatidiform mole (occurs with and without embryo, and multiple pregnancy)

49
Q

Heart nodules (granulomatous)

A

Aschoff bodies (rheumatic fever)

50
Q

Heterophile Ab

A

Infectious mononucleosis (EBV)

51
Q

Hexagonal, double-pointed, needle-like crystal in bronchial secretions

A

Bronchial asthma (Charcot-Leyden crystals; eosinophilic granules)

52
Q

High level of D-dimers

A

DVT, PE, DIC

53
Q

Hilar lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)

A

Ghon complex (primary TB; mycobacterium bacilli)

54
Q

Honeycomb lung on CXR or CT

A

Interstitial pulmonary fibrosis

55
Q

Hypercoagulability (leading to migrating DVTs and vasculitis)

A

Trousseau syndrome (adenocarcinoma of pancreas or lung)

56
Q

Hypersegmented neutrophils

A

Megaloblastic anemia (B12 deficiency-neurologic symptoms; folate deficiency-no neurologic symptoms)

57
Q

Hypertension, hypokalemia, metabolic alkalosis

A

Primary hyperaldosteronism (Conn syndrome)

58
Q

Hypochromic, microcytic anemia

A

Iron deficiency anemia, lead poisoning, thalassemia (fetal Hgb sometimes present)

59
Q

Intranuclear eosinophilic droplet-like bodies

A

Cowdry type A bodies (HSV or VZV)

60
Q

Iron containing nodules in alveolar sputum

A

Ferruginous bodies (asbestosis: increased chance for mesothelioma)

61
Q

Keratin pearls on a skin biopsy

A

Squamous cell carcinoma

62
Q

Large granules in phagocytes, immunodeficiency

A

Chediak-Higashi disease (congenital failure of phagolysosome formation)

63
Q

“Lead pipe” appearance of colon on abdominal imaging

A

Ulcerative colitis (loss of haustra)

64
Q

Linear appearance of IgG deposition on glomerular and alveolar basement membranes

A

Goodpasture syndrome

65
Q

Low serum ceruloplasmin

A

Wilson disease (hepatolenticular degeneration)

66
Q

“Lumpy-bumpy” appearance of glomeruli on immunofluorescence

A

Poststreptococcal glomerulonephritis (due to deposition of IgG, IgM, and C3)

67
Q

Lytic “punched out” bone lesions on XR

A

Multiple myeloma

68
Q

Mammary gland “blue domed” cyst

A

Fibrocystic change of the breast

69
Q

Monoclonal Ab spike

A 
Multiple myeloma (usually IgG or IgA)
Monoclonal gammopathy of undetermined significance (MGUS, consequence of aging)
Waldenstrom (M protein = IgM) macroglobulinemia 
Primary amyloidosis
70
Q

Mucin-filled cell with peripheral nucleus

A

Signet ring cells of gastric carcinoma

71
Q

Narrowing of bowel lumen on barium XR

A

String sign (crohn disease)

72
Q

Necrotizing vasculitis (lungs) and necrotizing glomerulonephritis

A

Granulomatosis with polyangitis (Wegener; PR3-ANCA/c-ANCA) and Goodpasture syndrome (anti-basement membrane Ab)

73
Q

Needle-shaped crystals, negative birefringent

A

Gout (monosodium urate crystals)

74
Q

Nodular hyaline deposits in glomeruli

A

Kimmelsteil-Wilson nodules (diabetic nephropathy)

75
Q

Novobiocin response

A

Sensitive: S.epidermidis
Resistant: S.saprophyticus

76
Q

“Nutmeg” liver

A

Chronic passive congestion of liver due to right heart failure of Budd-Chiari syndrome

77
Q

“Onion skin” periosteal reaction

A

Ewing sarcoma (malignant small blue cell tumor)

78
Q

Optochin response

A

Sensitive: S.pneumoniae
Resistant: Viridans streptococci (S.mutans, S.sanguis)

79
Q

Podocyte fusion or “effacement” on electron microscopy

A

Minimal change disease (child with nephrotic syndrome)

80
Q

Polished, “ivory-like” appearance of bone at cartilage erosion

A

Eburnation (osteoarthritis resulting in bony sclerosis)

81
Q

Protein aggregates in neurons from hyperphosphorylation of tau protein

A

Neurofibrils ray tangles (ALZ) and Pick bodies (Pick disease)

82
Q

Psammoma bodies

A

meningiomas, papillary thyroid carcinoma, mesothelioma, papillary serous carcinoma of the endometrium and ovary

83
Q

Pseudopalisading tumor cells on brain biopsy

A

Glioblastoma multiforme

84
Q

Raised periosteum (creating a “Codman triangle”)

A

Aggressive bone lesion (eg osteosarcoma, Ewing sarcoma, osteomyelitis)

85
Q

RBC casts in urine

A

Glomerulonephritis

86
Q

Rectangular, crystal-like, cytoplasmic inclusions in Leydig cells

A

Reindeer crystals (Leydig cell tumor)

87
Q

Recurrent infections, eczema, thrombocytopenia

A

Wiskott-Aldrich syndrome

88
Q

Renal epithelial casts in urine

A

Intrinsic renal failures (eg ischemia or toxic injury)

89
Q

Rhomboid crystals, + birefringent

A

Pseudo gout (calcium pyrophosphate dihydrate crystals)

90
Q

Rib notching (inferior surface seen on XR)

A

Coarctation of the aorta

91
Q

Ring-enhancing brain lesion on CT/MRI in AIDS

A

Toxoplasma gondii, CNS lymphoma

92
Q

Sheets of medium-sized lymphoid cells with scattered pale, tingible body-laden MPs (starry sky histology)

A

Burkitt lymphoma (t[8:14] c-myc activation, associated with EBV, starry sky made up of malignant cells

93
Q

Silver-staining spherical aggregation of tau proteins in neurons

A

Pick bodies (Pick disease: progressive dementia, changes in personality)

94
Q

Soap bubble in femur or tibia on XR

A

Giant cell tumor of bone (usually benign)

95
Q

Spikes on basement membrane, dome-like sub epithelial deposits

A

Membranous nephropathy (nephrotic syndrome)

96
Q

stacks of RBCs

A

Rouleaux formation (high ESR, multiple myeloma)

97
Q

Steeple sign on frontal CXR

A

Croup (parainfluenza virus)

98
Q

Stipples vaginal epithelial cells

A

Clue cells (Gardnerella vaginalis)

99
Q

Streptococcus Boris bacteremia

A

Colon cancer

100
Q

Tennis racket shaped cytoplasmic organelles (EM) in Langerhans cells

A

Birbeck granules (Langerhans cell histiocytosis)

101
Q

Thousands of polyps on colonoscopy

A

Familial adenomatous polyposis (AD, mutation of APC gene)

102
Q

Thrombi made of white/red layers

A

Lines of Zahn (arterial thrombus, layers of platelets/RBCs)

103
Q

Thumb sign on lateral neck XR

A

Epiglottitis (Haemophilus influenzae)

104
Q

Thyroid like appearance of kidney

A

Chronic pyelonephritis (usually due to recurrent infections)

105
Q

Tram-track appearance of capillary loops of glomerular basement membranes on light microscopy

A

Membranoproliferative glomerulonephritis

106
Q

Triglyceride accumulation in liver cell vacuoles

A

Fatty liver disease (alcoholic or metabolic syndrome)

107
Q

Increased uric acid levels

A

Gout, Lesch-Nyhan syndrome, tumor lysis syndrome, loop and thiazide diuretics

108
Q

Waxy casts with very low urine flow

A

Chronic end-stage renal disease

109
Q

WBC casts in urine

A

Acute pyelonephritis

110
Q

WBCs that looked “smudged”

A

CLL (almost always BC)

111
Q

Wire loop glomerular capillary appearance on light microscopy

A

Diffuse proliferation glomerulonephritis (usually seen with SLE)

112
Q

Yellowish CSF

A

Xanthochromia (eg due to subarachnoid hemorrhages)

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