Classic Key Associations Flashcards
Actinic Keratosis
Precursor to squamous cell carcinoma
Acute gastric ulcer associated with CNS injury
Cushing ulcer (increase ICP stimulates vagal gastric H+ secretions)
Acute gastric ulcer associated with severe burns
Curling ulcer (greatly reduced plasma volume results in sloughing of gastric mucosa)
Age ranges for patient with ALL/CLL/AML/CML
ALL:child
CLL: adult > 60yo
AML: adult ~60yo
CML: adult 45 - 85yo
Alternating areas of transmural inflammation and normal colon
Skip lesions of Crohn disease
Aortic aneurysm, abdominal
Atherosclerosis
Aortic aneurysm, ascending or arch
Tertiary syphilis (syphilitic aortitis), vasa vasorum destruction
Aortic aneurysm, thoracic
Marfan syndrome (idiopathic cystic medial degeneration)
Aortic dissection
HTN
Atrophy of the mammillary bodies
Wernicke encephalopathy (thiamine deficiency causing ataxia, ophthalmoplegia, and confusion)
Autosplenectomy (fibrosis and shrinkage)
Sickle cell disease (hemoglobin S)
Bacteria associated with gastritis, PUD, gastric malignancies (adeno, MALToma)
H pylori
Bacterial meningitis (adults and elderly)
S pneumo
Bacterial meningitis (newborns and kids)
GBS/E coli (newborn)
S pneumo/N meningitidis (kids)
Bilteral ovarian metastases from gastric carcinoma
Krukenberg tumor (mucin-secreting signet rings cells)
Bleeding disorder with Gp1b deficiency
Bernard-Soulier syndrome (defect in platelet adhesion to vWF)
Breast cancer
invasive ductal carcinoma
Breast mass
fibrocystic change, carcinoma (in postmenopausal women)
Breast tumor (benign, young woman)
fibroadenoma
Cardiac tumor, (kids)
Rhabdomyoma, seen in tuberous sclerosis
Cardiac manifestations of SLE
Marantic/thrombotic endocarditis (nonbacterial)
Cardiac tumor, (adults)
Metastasis, myxoma in LA “ball and valve”
Cerebellar tonsillar herniation
Chiari II malformation
Chronic arrhythmia
A fib, associated with high risk of emboli
Chronic atrophic gastritis (autoimmune)
Predisposition to gastric carcinoma (can also cause pernicious anemia)
CAH hypotension
21-hydroxylase deficiency
Constrictive pericarditis
TB (worldwide), viral illness (developed world
Coronary artery involvement in thrombosis
LAD > RCA > circumflex
Cretinism
Iodine deficit/congenital hypothyroidism
Cushing syndrome
- Iatrogenic (from tx)
- Adrenocortical adenoma
- ACTH-secreting pituitary adenoma (Cushing disease)
- Paraneoplastic (due to ACTH secretion by tumors)
Cyanosis (early; less common)
TOF, Transposition of great vessels, Truncus arteriosus
Death in CML
Blast crisis
Death in SLE
Lupus nephropathy
Ejection click
Aortic stenosis
Esophageal cancer
Squamous cell carcinoma (worldwide), Adenocarcinoma (US)
Helminth infection (US)
Enterobius vermicularis, Ascaris lumbricoides
Hemochromatosis
Multiple blood transfusions or hereditary HFE mutation (can result in heart failure, “bronze diabetes,” and increased risk of hepatocellular carcinoma)
Hepatocellular carcinoma
Cirrhotic liver (associated with Hep B, Hep C and alcoholism)
Holosystolic murmur
VSD, tricuspid regurgitation, mitral regurgitation
HTN, secondary
renal artery stenosis Chronic kidney disease Polycystic kidney disease Diabetic nephropathy Hyperaldosteronism
Hypopituitarism
Pituitary adenoma
Infection 2/2 blood transfusion
Hep C
Infections in CGD
S Aureus, E coli, Aspergillus (catalase +)
Intellectual disability
consider Down and Fragile X
Kidney stones
- Calcium = radiopaque
- Struvite = radiopaque and 2/2 infxn by urease + Proteus, Klebsiella, S saprophyticus
- Uric acid = radiolucent
- Cystine = radiolucent
Late cyanotic shunt (uncorrected left to right becomes right to left)
Eisenmenger syndrome (caused by ASD, VSD, PDA; results in pulmonary HTN/polycythemia)
Malignancy associated with non-infectious fever
Hodgkin Lymphoma
Malignancy in kids
ALL, medulloblastoma (cerebellum)
Metastases to bone
Prostate, breast > lung > thyroid
Metastases to brain
Lung > breast > GU > melanoma > GI
Metastases to liver
Colon»_space; stomach, pancreas
Mitral valve stenosis
Rheumatic heart disease
Myocarditis
Consider coxsackie B
Nephrotic syndrome (adults)
Focal Segmental glomerulosclerosis
Nephrotic syndrome (kids)
Minimal change disease
Neuron migration failure
Kallmann syndrome (hypogonadotropic hypogonadism and anosmia)
Nosocomial pneumonia
S Aureus, Pseudomonas, other enteric gram - rods
Obstruction of male urinary tract
BPH
Opening snap
Mitral stenosis
Osteomyelitis in general
S Aureus
Osteomyelitis in sick cell patient
Salmonella
Osteomyelitis in IVDA
Pseudomonas, Candida, S Aureus
Ovarian tumor (benign)
Serous cystadenoma
Ovarian tumor (malignant)
Serous cystadenocarcinoma
Pancreatitis (acute)
Gallstones, alcohol
Pancreatitis (chronic)
Alcohol (adults), CF (kids)
Primary Amenorrhea
Consider Turner syndrome
Primary bone tumors (adults)
Multiple myeloma
Primary hyperaldosteronism
Adenoma of adrenal cortex
Primary hyperparathyroidism
Adenoma, hyperplasia, carcinoma
Primary liver cancer
Hepatocellular carcinoma (chronic hepatitis, cirrhosis, hemochromatosis, alpha1-antitrypsin deficiency, Wilson disease)
Recurrent inflammation, thrombosis of small to medium vessels in extremities
Buerger disease (strongly associated with tobacco) "segmental thrombosing vasculitis"
Refractory peptic ulcers and high gastrin levels
Z-E syndrome (gastrinoma of duodenum or pancreas), associated with MEN1
Renal tumor
Renal cell carcinoma: associated with von-Hippel-Lindau and cigarette smoking; paraneoplastic syndrome (EPO, renin, PTHrP, ACTH)
S3 heart sound
increase ventricular filling pressure (mitral regurgitation, HF), common in dilated ventricles
S4 heart sound
Stiff/hypertrophic ventricle (aortic stenosis, restrictive cardiomyopathy)
Secondary hyperparathyroidism
Hypocalcemia of chronic renal disease
Site of diverticula
Sigmoid colon
Sites of atherosclerosis
Abdominal Aorta
Coronary artery
Popliteal artery
Carotid artery
Temporal arteritis
Risk of ipsilateral blindness due to occlusion of ophthalmic artery
Polymyalgia rheumatica
Testicular tumor
Seminoma (malignant, radiosensitive), increase placental ALP
Thyroid cancer
Papillary carcinoma (childhood irradiation)
Tumor of infancy
Strawberry hemangioma (grows rapidly and regresses spontaneously by childhood)
Tumor of adrenal medulla (adults)
Pheochromocytoma (usually benign)
5 P’s
increase catecholamines and metanephrines in urine and plasma (VMA)
Tumor of adrenal medulla (kids)
Neuroblastoma (malignant) increase HVA & VMA Homer-Wright rosettes CROSSES MIDLINE!! Opsoclonus-myoclonus syndrome
Type of Hodgkin Lymphoma
Nodular sclerosing (vs. mixed cellular, lymphocytic predominance, lymphocytic depletion)
Type of non-Hodgkin Lymphoma
Diffuse large B-cell lymphoma
UTI
E coli S saprophyticus (young women)
Vertebral compression fracture
Osteoporosis (type I: postmenopausal woman; type II: elderly man or woman)