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Immunoserology > Classes of Immunoglobulins > Flashcards

Classes of Immunoglobulins Flashcards

1
Q

Predominant in healthy humans

A

IgG

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2
Q

Provides immunity to newborn

A

IgG

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3
Q

How does IgG provides immunity to newborn?

A

IgG is the smallest Ig which makes them easily cross the placenta

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4
Q

Subclass(es) of IgG that can cross placenta

A

IgG1 and IgG3

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5
Q

One function of IgG is fixation of complement. Arrange IgG based on the potency from greatest to least: IgG1, IgG2, IgG3.

A

IgG3 –> IgG1 –> IgG2

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6
Q

What are the molecules that enhances phagocytosis?

A

Opsonin

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7
Q

This enhances the phagocytosis by facilitating the linking or cross-bridging of phagocytes and target antigen

A

Opsonization

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8
Q

Type of immunity that provides immunity to the newborn from the maternal antibody

A

Acquired Natural Passive Immunity

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9
Q

This immunoglobulin is predominant antibody in the Secondary or Anamnestic Response

A

IgG

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10
Q

This immunoglobulin is a monomer and has no J Chain

A

IgG

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11
Q

This immunoglobulin is the best precipitating antibody

A

IgG

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12
Q

This immunoglobulin participates in agglutination and precipitation reaction

A

IgG

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13
Q

The four (4) subclasses of IgG are differentiated based on: (2)

A
  1. Concentration in the serum
  2. number of disulfide bonds
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14
Q

Concentration and number of disulfide bonds: IgG1

A

66%
2 disulfide bonds

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15
Q

Concentration and number of disulfide bonds: IgG2

A

23%
4 disulfide bonds

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16
Q

Concentration and number of disulfide bonds: IgG3

A

7%
15 disulfide bonds

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17
Q

Concentration and number of disulfide bonds: IgG4

A

4%
2 disulfide bonds

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18
Q

This immunoglobulin is predominant in primary immune response

A

IgM

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19
Q

This immunoglobulin First antibody displayed on B cell Surface

A

IgM

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20
Q

This immunoglobulin
first to appear in phylogeny and last to leave in senescence

A

IgM

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21
Q

This immunoglobulin
first to appear after a primary antigenic stimulus

A

IgM

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22
Q

Best antibody in terms of fixing the Complement

A

IgM

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23
Q

Biggest antibody – Composed of 5 monomers
(Pentameric Antibody)

A

IgM

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24
Q

Functions of IgM (4)

A

▪ Complement Fixation
▪ Agglutination
▪ Opsonization
▪ Toxin neutralization

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25
Q

Best agglutinating antibody

A

IgM

26
Q

This immunoglobulin exists as monomer or dimer

A

IgA

27
Q

IgA is a monomer in:

A

Plasma

28
Q

IgA is a dimer in:

A

Secretion

29
Q

Responsible for mucosal immunity

A

IgA

30
Q

Immunoglobulin that is predominant in secretion/body fluids

A

IgA

31
Q

Only antibody with secretory component

A

IgA

32
Q

Responsible in maintaining the structure of antibody by preventing the enzymatic degradation of the structure

A

secretory component

33
Q

plays a role in the binding of IgA to the Epithelial mucosal surface

A

Secretory component

34
Q

Function is still unknown but believes to play a role in
immunoregulation

A

IgD

35
Q

Second to IgM to be expressed on the surface of B Lymphocytes

A

IgD

36
Q

Postulated to be an anti-idiotypic antibody

A

IgD

37
Q

Least abundant Ig in the healthy serum

A

IgE

38
Q

IgE is abundant in which type of parasitic infection?

A

Helminthic

39
Q

IgE is present in which type of hypersensitivity

A

Type 1 Hypersensitivity

39
Q

IgE is present in which type of hypersensitivity

A

Type 1 Hypersensitivity

40
Q

Only Ig that binds strongly to mast cell and Basophil
receptor

A

IgE

41
Q

Why can IgE bind to mast cells and basophil?

A

It has specific receptor to mast cells and basophil

42
Q

Mediator of allergic reaction

A

Histamine

43
Q

Site for histamine receptor

A

Basophil and Mast Cell

44
Q

Mast cells are found in:

A

Tissues

45
Q

Basophils are found in:

A

Circulation

46
Q

Molecular weight of IgG

A

150 T

47
Q

Molecular weight of IgA

A

160 - 400 T

48
Q

Molecular weight of IgM

A

900 T

49
Q

Molecular weight of IgD

A

180 T

50
Q

Molecular weight of IgE

A

190 T

51
Q

Half life of IgG

A

21-23 days

52
Q

Half life of IgA

A

5-6 days

53
Q

Half life of IgM

A

5 days

54
Q

Half life of IgD

A

2-3 days

55
Q

Half life of IgE

A

2-3 days

56
Q

Other name for IgG

A

Serum Ig

57
Q

Other name for IgA

A

Secretory Ig

58
Q

Other name for IgM

A

Pentameric Ig

59
Q

Other name for IgE

A

Reagenic Ig

60
Q

Which complement does IgA activate?

A

Alternative Pathway only

Immunoserology (4 decks)

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