Class III Antiarrhythmic

Question 1

Amiodarone
Dofetilide
Sotalol

Answer 1

Block potassium channels and slow the outward movement of potassium during phase 3 of the action potential, prolonging it.

Question 2

THERAPEUTIC ACTION

How does this drug work in our body?

Answer 2

Block potassium channels and slow the outward movement of potassium during phase 3 of the action potential
This action prolongs the action potential

Question 3

INDICATIONS

Why are we giving this drug?

Answer 3

Life-threatening ventricular arrhythmias

Maintenance of sinus rhythm after conversion of atrial arrhythmias

Question 4

CONTRAINDICATIONS

When NOT to give drug

Answer 4

When used for life-threatening arrhythmias there is no contraindication

Question 5

CAUTION

Answer 5

Shock, hypotension, respiratory depression, prolonged QT interval, renal or hepatic disease

Question 6

ADVERSE EFFECTS

What to monitor for

Answer 6

Nausea
vomiting
weakness
 dizziness
arrhythmia

Question 7

DRUG -DRUG INTERACTIONS

Answer 7

Digoxin
Quinidine
Other specific drug interactions vary with individual drugs

Question 8

PROTOTYPE

Answer 8

Amiodarone