CLASS II Antiarrhythmic (-olol’s)

Question 1

Acebutolol
Esmolol
Propranolol

Answer 1

Beta-adrenergic blockers block beta-receptors, causing a depression of phase 4 of the action potential

Question 2

THERAPEUTIC ACTIONS

How does this work in our body?

Answer 2

Competitively block beta receptor sites in the heart and kidneys
Decrease heart rate, cardiac excitability, and cardiac output
Slow conduction though the AV node

Question 3

INDICATIONS

Why are we giving this drug?

Answer 3

Competitively block beta receptor sites in the heart and kidneys
Decrease heart rate, cardiac excitability, and cardiac output
Slow conduction though the AV node

Question 4

CONTRAINDICATIONS

When NOT to give the drug

Answer 4

Sinus bradycardia
AV block
cardiogenic shock CHF
asthma, or respiratory depression
 pregnancy and lactation

Question 5

CAUTIONS

Answer 5

Diabetes
thyroid dysfunction
renal or hepatic dysfunction

Question 6

ADVERSE EFFECTS

What to monitor for

Answer 6

Related to the effects of blocking beta receptors in the sympathetic nervous system

CNS – Dizziness, insomnia, dreams, and fatigue

CV – Hypotension, bradycardia, AV block, arrhythmias

Respiratory – Bronchospasm and dyspnea

GI – Nausea, vomiting, anorexia

Misc. – Loss of libido, decreased exercise tolerance, alterations in blood glucose levels

Question 7

DRUG- DRUG INTERACTIONS

Answer 7

Verapamil

Insulin

Question 8

PROTOTYPE

Answer 8

Propranolol