Class 6 Flashcards
True or False: In past decades cervical carcinoma was more common than endometrial carcinoma worldwide
True
True or False: In USA, endometrial carcinoma is more common than Cervical Carcinoma
True
Why is Cervical Carcinoma more common in USA than endometrial carcinoma?
- Early diagnosis of cervical CA with PAP smear and cone biopsy
- Increased patient life span
- Postmenopausal estrogen use
What are risk factors for development of endometrial carcinoma?
- OBESITY
- DIABETES
- HIGH BLOOD PRESSURE
- SHORT IN HEIGHT
- JEWISH
- AGE (postmenopausal)
- ESTROGEN USE AFTER MENOPAUSE
What are some of the effects of endometrial carcinoma?
- Dysfunctional uterine bleeding without ovulation
- Hyperplasia of the endometrium
- Polycystic ovaries (Stein-Leventhal Syndrome)
- Theca Granulosa Cell tumor
- Tamoxifen use for breast cancer
Where does endometrial carcinoma begin? Where does it grow to?
It begins in the endometrium then grows toward the myometrium
True or False. The greater degree of infiltration of endometrial carcinoma into the myometrium, the GREATER the prognosis
False: The greater degree of infiltration of endometrial carcinoma into the myometrium, the POORER the prognosis
What determines the STAGE of endometrial carcinoma?
The degree of tumor spread
What determines the GRADING of endometrial carcinoma?
The Tumor differentiation
What are the signs and symptoms of Endometrial Carcinoma?
- Bleeding or discharge after menopause
- PAIN
What are some treatment options for Endometrial Carcinoma?
- Complete hysterectomy with bilateral oophorectomy
- Lymphadenectomy
- Pre or Post Operative radiation therapy
- Chemotherapy
US appearance of Endometrial Carcinoma
- Uterus may appear normal
- Uterus may be increased in size
- Endometrium may be thickened
- Endometrial cavity may be fluid filled
What are some of the differential diagnoses for Endometrial Carcinoma?
- ENDOMETRIAL HYPERPLASIA
- ENDOMETRIAL POLYPS
- LEIOMYOMA
- CERVICAL CARCINOMA (causing hematometra or pyometra)
True or False: Leiomyosarcoma is the MALIGNANT counterpart of Fibroid
True
Is Leiomyosarcoma common or rare? What is the percentage of uterine tumors?
Rare and 3% of uterine tumors
If a fibroid has a growth spurt, what malignancy is suspected?
Leiomyosarcoma
What age is Leiomyosarcoma most common?
50’s
Can an Ultrasound distinguish leiomyoma from Leiomyosarcoma?
No
True or False: On an ultrasound a Leiomyosarcoma may present as inhomogeneous uterine mass with areas of cystic degeneration
True
What are some risk factors for Cervical Carcinoma?
- EARLY SEXUAL ENCOUNTERS
- MULTIPLE SEXUAL PARTNERS
- INFECTION BY STD OR A SEX PARTNER WHO HAS AN STD
- HUMAN PAPILLOMA VIRUS (causes genital warts)
What is the most common cell type for Cervical Carcinoma?
Squamous cells
True or False: The prognosis for Cervical Carcinoma does not depend on the stage at diagnosis
False: PROGNOSIS DEPENDS ON STAGE AT DIAGNOSIS