Class 3 Flashcards
CBT for SAD
exposure (rehearsals: start with simple things then work your way up/ flooding) + restructuring and challenging maladaptive thoughts: when people have negative emotions = negative thoughts, vicious cycle. Thoughts: I’m not good enough, people don’t lie me, I’m weak and people can see that. Pretend survey. Talk to a friend/ coworker.
How to chose Rx
Family members? Taken? Side effects? Half life (manic switch)?
1st line SAD
SSRI: escitalopram(Cipralex), fluvoxamine + CR, paroxetine + CR, sertraline
SNRI: Venlafaxine XR
Pregabalin
Side effects SSRI
: no, diarrhea, headache, insomnia, irritability, increased anxiety, somnolence (2 weeks), long term: weight gain, sexual dysfunction. GI, heart problems, manic symptoms, bipolar in the family
Which SSRIs are associated with less weight gain
• fluoxetine, citalopram and sertraline associated with less weight gain than paroxetine.
Which SSRI is associated with more sexual side effects and more withdrawal symptoms
paroxetine
Which SSRI is associated with more diarrhea
sertraline
Which SSRI is associated with less withdrawal symptoms
fluoxetine
Which SSRI to use if patient also has pain
paroxetine and duloxetine
Which class of antidepressants increases chances of GI bleeding
SSRI
Which classes of antidepressants are associated with QTc prolongation
Tricyclic and tetracyclic antidepressants and selective serotonin reuptake inhibitors.
SNRIs have a better side effect profile
Risk factors for QT prolongation
Heart disease or cardiac abnormalities Over 65 Female Electrolyte abnormalities (hypoCa/Mg) Bradycardia Genetic factors/ congenital QT syndrome
Antidepressants with higher risk of QTc prolongation
citalopram, escitalopram, venlafaxine, mirtazapine, amitriptyline, imipramine, nortriptyline, clomipramine, trimipramine, desipramine, maprotiline, mirtazapine
2n line SAD
Benzo: clonazepam, alprzolam, bramazepam:
Antidep: citalopram (celexa), phenlazine
Anticonvuls: gabapentin
Why use benzos SAD
single presentation, try medication before, 2 weeks away, help with exposure.
Side effects benzos
sedation, dizziness, weakness, ataxia, decreased motor performance, DEPENDANCE, WITHDRAWAL.
Side effects MAOIs
Dry mouth, Nausea, diarrhea or constipation, Headache, Drowsiness, Insomnia, Dizziness or lightheadedness. MAOIscan cause dangerous interactions with certain foods and beverages. You’ll need to avoid foods containing high levels of tyramine ― an amino acid that regulates blood pressure
Side effects gabapentin
GI, weight gain, somnolence, tremor, rash, toxic epidermal necrolysis
SAD performance only Rx
Propanolol, Tenormin; block beta adrenergic receptor activity
SSRIs: onset, full response, titrage dose
2-8 weeks onset of symptom relief. Full response: 12 weeks. Titrage dose: every 1-2 weeks.
Aggravating factors SAD
general stress, big life events, depression
signs of relapse SAD
morbid state, start avoiding more, difficulty sleeping, low mood, isolation, low energy, trouble concentrating
Goal of therapy
you can learn to tolerate and cope with the things you’re afraid of, better than you think you can, not be so frightened of your fear, more confidence in your ability to get through it
Tolerability of therapy
it’s going to be hard, work on your part, what you do outside of therapy.