class 2 antiarrythmic: BB

Question 1

effects of class 2 antiarrythmics

Answer 1

action via increasing cAMP=> decreases Na + ca current + suppress abnormal pacemaker/ decrease slope of PHASE 4 - > next ap delayed-> bradycardia (so an increase in RR interval)

Question 2

drugs

Answer 2

metoprollol, propanolol, esmolol, sotalol

Question 3

metoprolol

Answer 3

action: cardioselective b1, na ch inhibition, decrease risk
i: tachyarrythmias b/c increase in SYM, Afib, Aflutter, AVNRT, prevent ventricular arrythmia after MI
contraindication: heartblock, bradyarrythmia
AE: AV block, cold extremeties, impotence, hypercholesteremia, bradycardia, nightmares

Question 4

propanolol

Answer 4

action: non selective, Na ch block, strongest
i: tachyarrythmias b/c increase in SYM, Afib, Aflutter, AVNRT, prevent ventricular arrythmia after MI
contraindication: heartblock, bradyarrythmia
AE: AV block, cold extremeties, impotence, hypercholesteremia, bradycardia, nightmares

Question 5

esmolol

Answer 5

non - selective, short duration of action + fast onset, admin parenterally
i: tachyarrythmias b/c increase in SYM, Afib, Aflutter, AVNRT, prevent ventricular arrythmia after MI
contraindication: heartblock, bradyarrythmia
AE: AV block, cold extremeties, impotence, hypercholesteremia, bradycardia, nightmares

Question 6

sotalol

Answer 6

non selective, k ch inhibitor
i: tachyarrythmias b/c increase in SYM, Afib, Aflutter, AVNRT, prevent ventricular arrythmia after MI
contraindication: heartblock, bradyarrythmia
AE: AV block, cold extremeties, impotence, hypercholesteremia, bradycardia, nightmares