23.hypertension 2 (Ca ch. blockers + vasodilation)

Question 1

MOA

Answer 1

-Ca intercellularly maintains tone of SMC + myocardial cells. enters through VGCC triggering SR to release more Ca leading to muscle contraction
-Ca ch, blockers inhibit the L type VGCC in vascular SMC
myocardium, and vasodilation leading to: decrease in CO, TPR, Ic Ca

Question 2

pharmacokinetics

Answer 2

increase in plasma proetin binding,

inactivates CYP3A4

Question 3

drug interactions

Answer 3

Dynamic: verapamil/ diltiazam + BB => AV BLOCK

-kinetic: verapamil + digoxin => enhances

Question 4

Adverse effects

Answer 4

• cardiac: av block, cardiac depression, brady cardia
• hypotension
• dizziness
• heachache
• angioedema
• nasuea
• constipation

Question 5

contraindications

Answer 5

pregnancy

-short acting DHP in IHD