Class 1 Flashcards
ARFID criteria
Avoidance or restriction of food intake characterized by eating a quantity or variety of foods insufficient to respond to energy or nutritional needs leading to one or more of the following:
–Loss of weight (or inability to gain expected weight);
–Significant nutritional deficits;
–Dependence upon nutritional supplements
–Marked interference with psychosocial functioning.
ARFID m=W?
a little more common than anorexia in males
Sub-types ARFID
Fear of negative consequences (orthorexia)
Loss of interest
Sensory Sensitivity
RESTRICTER comorbid
anx, dep (50%), compulsivity, preference for order. Overregulation.
BINGER/PURGER comorbid
substance abuse (50%), impulsivity, parasuicidality, lability, anxiety, dep. Dysregulation
Perinatal Factors
•Sex hormone exposure in utero: brain makes serotonin out of tryptophan which it gets only
with eating so if you diet you lose serotonin. even 2-3 weeks women are more sensitive to that due to estrogen. ring finger longer than index = more estrogen = more at risk of ED
•Obstetric complications
•Combined obstetric complications and childhood stress
•Season of birth: developing a more serotonergic environment
•In utero exposure to viral infection
Risk factors Development
- No necessity of adversity
- Inconsistent association with anxious or unstable attachments
- Association with childhood trauma and adult victimization experiences (in binge-purge variants)
Risk factors Family
- No ED-prone family
- No special meal-related problems
- No excessive parental body-image concerns
- No pre-requisite family dysfunction
Are there genetic factors involved?
50% explained by genetic factors alone
The genetic architecture of AN implicates
psychiatric disorders, metabolic factors and anthropometric traits
Is there a link between AN and immune function?
Significant relationships between previous celiac, Crohn’s, ulcerative colitis, psoriasis, type-1 diabetes and later EDs.
Significant relationships between previous AN, BN, AED or OED and Any Autoimmune disease.
Transactional model
Genes (•Brain function and psychiatric disorders, Metabolism, set point, Immune function) X Environments (Perinatal, Developmental, Current)
genetic factors need to be turned on by the enviro
DNA Methylation
if methyl binds to promoter = no gene expression.
Nutrients contribute to methylation. If you don’t eat = mess your methylation and the way your DNA produces proteins
The ED Trajectory
genetic susceptibility + obstetric/ perinatal insults + developmental stress + life stress + dieting
Hospitalise or not?
- Hospitalization not associated with favorable outcome
* no difference really between short or long hospit on long term outcome
Main Practice Principles
- Not coercive
- Ensure safety
- Encourage re-evaluation of beliefs and values
- Encourage experimentation with behaviors that put mistaken beliefs to the test: Did you pat the dog today?
- Go for personal engagement (« Is this really in your best interest? »)