CLASP - sepsis (micro) Flashcards
Tx for C.diff
1st: Oral vancomycin
2nd: Fidaxomicin
3rd: Oral vancyomycin +/- IV metronidazole
In life-threatening toxic megacolon, a subtotal colectomy may be required
T or F: alcohol-based hand rubs are not effective in removing C. difficile spores
True - use water and soap
Fever, rash, relative bradycardia and abdominal pain plus leukopaenia and raised transaminases in a returning traveller
Salmonella typhi
When is vaginal therapy indicated in a pregnant woman with HIV?
Viral load <50 at 36 weeks
Rapid onset vomiting after having home-made foods and dairy products + non-bloody diarrhoea
Staphylococcus aureus
Serious side effect of the use of penicillins?
Anaphylactic shock
Spectrum of activity of penicillin
Covers gram-positive (S. aureus, S. pneumoniae, S. viridans, ß-haemolytic Streptococci, Bacillus anthracis, Clostridium tetani); spectrum increased with ß-lactamase inhibition
Spectrum of activity of flucloxacillin
Penicillinase resistant
Spectrum of activity of amoxicillin
Similar to penicillin + gram-negative cover (E. coli, Brucella spp., H. influenzae)
Spectrum of activity of Glycopeptides
Gram-positive coverage (aerobic and anaerobic)
Spectrum of activity of Linezolid
Gram-positive infection (including MRSA)
Spectrum of activity of Aminoglycosides
Broad-spectrum gram-negative cover e.g. E. coli, P. aeruginosa
Spectrum of activity of Fluoroquinolones
Broad-spectrum antibiotic coverage
Spectrum of activity of Tetracyclines
Broad-spectrum gram-positive, gram-negative and intracellular cover; some gram-positive cocci resistance
Spectrum of activity of Macrolides
Similar to penicillins with cover for multiple causes of atypical pneumonia
Spectrum of activity of Metronidazole
Significant anaerobic cover and protozoan cover
Aerobic, haemolytic gram-positive bacillus
Listeria
Spore-forming, toxin-producing gram-positive bacillus; found in cattle and sheep
Bacillus anthracis
Toxin-producing gram-positive bacillus. Causes gastroenteritis. Found in re-heated takeaway food (typically rice); re-heating kills bacteria but not toxins
Bacillus cereus
Anaerobic, spore-forming gram-positive bacilli; typically found in soil and dust
Clostridium
Rod-shaped, a nonmotile, non-encapsulated obligate aerobe
Mycobacterium tuberculosis/bovis
Mechanism of trimethoprim?
Inhibits the folic acid synthesis pathway
Contraindication to the use of trimethoprim?
Pregnancy
Adverse effect of quinolone antibiotics?
C. difficile superinfection
Haematogenous osteomyelitis, causative agent likely to be..
Staphylococcus aureus
What does the following gram stain show?
Staphylococcus aureus/Staph epidermis if coag positive
Gram positive clusters
What is strep pneumonia?
Gram-positive, α-hemolytic, lancet-shaped diplococci
Blue-green pigment is noted on the agar plate
Pseudomonas aeruginosa
8 year old with sore throat and fever
Anterior cervical lymphadenopathy
Blood agar, which shows growth of colonies surrounded by a clear zone
Strep throat - Strep pyogens (GAS - beta haemolytic)
History of cystic fibrosis. Blood culture shows gram negative rods
Pseudomonas aeruginosa
Abx for Pseudomonas aeruginosa
Erythromycin
Gram positive coccus that generally exists in pairs, or in chains
Streptococcus pyogenes
Streptococcus pneumoniae
Gram negative diplococci
Neisseria meningitidis
Gram positive cocci in clusters
Staphylococcus aureus
Drug to give if penicillin allergic
Macrolides - Clarithromycin, zithromycin and erythromycin
Drug to give if penicillin resistant
Vancomycin
Gram negative bacilli/rods
Shigella spp
Salmonella spp
Escherichia coli
Vibrio cholerae
Gram negative bacilli/rods:
K. pneumonia/E- coli if lactase positive
H. pylori/V. cholerae/ P. aeruginose if lactase negative
Which condition is an absolute contraindication to treatment with nitrofurantoin?
G6PD
Gram negative curved/spiral bacillus
Vibrio cholerae
Campylobacter jejuni
H. pylori
Which lab test would be most useful to identify strep pyogenes?
Anti-streptolysion O
Which lab test would be most useful to identify strep pneumoniae?
Quellung reaction
Abx for Campylobacter
Clarithromycin
Alt. ciprofloxacin
Abx for Salmonella
Ciprofloxacin
Abx for Shigellosis
Ciprofloxacin
Ix for Clostridioides difficile
CDT in the stool
Tx for UTIs
Ix for legionella
Urinary antigen
Tx for legionella
Erythromycin/clarithromycin
Fever, myalgia and fatigue 1 week after returning from Kenya
Mild jaundice and splenomegaly
Malaria
What type of bacteria is Campylobacter?
Gram-negative bacillus
Causes skin infections (e.g. cellulitis), abscesses, osteomyelitis, toxic shock syndrome
Coagulase-positive Staphylococcus aureus
Cause of central line infections and infective endocarditis
Coagulase-negative Staphylococcus epidermidis
Gram positive cocci
Staphylococci + streptococci (including enterococci)
Gram-negative cocci
Neisseria meningitidis + Neisseria gonorrhoeae, also Moraxella catarrhalis
Gram-positive rods (bacilli)
ABCD L
Actinomyces
Bacillus anthracis (anthrax)
Clostridium
Diphtheria: Corynebacterium diphtheriae
Listeria monocytogenes
Gram-negative rods (bacilli)
Escherichia coli
Haemophilus influenzae
Pseudomonas aeruginosa
Salmonella sp.
Shigella sp.
Campylobacter jejuni
Alternative to PO metronidazole in BV?
Topical metronidazole/clindamycin
Milk, cheese and eggs
Salmonella Typhimurium/Entereditis
BBQs
Campylobacter jejuni
Reheated rice
Bacillus cereus
Contaminated milk products and foods contaminated through contact with food workers who carry the bacteria
Food that require no cooking, including puddings, pastries, sandwiches and sliced meat
Staph aureus
Red meat
Clostridium perfringens
Improperly cooked or cheap cuts of meat and petting zoos or farms
E. coli
Tx for gastroenteritis
Ciprofloxacin/azithromycin
CURB 65
Confusion +/-
Urea >7
Respiratory Rate >30
Blood pressure: systolic < 90 or diastolic <60
More than 65 years old
Mx if CURB 65 is 0/1
Home-based care, give oral amoxicillin for 5 days (macrolide e.g. clarithromycin, doxycycline or tetracycline if penicillin allergic)
Mx if CURB 65 is 2
Hospital-based care, 7-10 day course of dual antibiotic therapy with amoxicillin (IV or oral) and a macrolide
Mx if CURB 65 is 3
Hospital/ITU-based care, 7-10 day course of dual antibiotic therapy with IV co-amoxiclav/ceftriaxone/tazocin and a macrolide.
Mx if HAP within 5 days of admission
Co-amoxicillin or cephalosporin (e.g cefuroxime)
Mx if HAP 5 days after admission
Tazocin or cephalosporin (e.g. ceftazidime) or quinolone
_____ is characteristic of haemolytic anaemia, thrombocytopenia and acute renal failure
E. coli 0157
Most common bacterial organism implicated in infections affecting the urinary tract
E coli