CLASP formative Flashcards
What is the most common cause of gastric marginal zone lymphomas?
H pylori
Which autoimmune disease is most associated with the development of cholangiocarcinoma?
Primary sclerosis cholangitis
What is PSA used for in prostatic cancer?
Diagnosis and monitoring (also detects benign prostatic hyperplasia)
What is personalised medicine in cancer therapy?
Targeting of the specific gene abnormalities
What is the second line investigation after a CXR with an opacity?
Contrast enhanced CT of the chest and abdomen
Where can lynch syndrome present?
Colon (ascending) and endometrial (uterine and bladder)
How does radiation mainly kill?
Damage of DNA strands
Which asbestos fibre is mainly associated with malignancy?
Chysotile
What cancers can asbestos causes?
Mesothelioma and adenocarcinoma
How does HPV promote carcinogenesis?
Degrading normally produced p53
Is gastric cancer related to obesity?
No
What syndrome increases risk of oesophageal adenocarcinoma and squamous cell carcinoma?
Adenocarcinoma = Barrets oesophagus SCC = Plummer Vinson syndrome
What mismatch repair is seen is lynch syndrome?
Microsatellite instability
What phase of the cell cycle does p53 cause arrest of?
Between G1 and S
Which viral hepatitis is most commonly associated with malignancy?
HepC
