CLASP Alcohol Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

How is methanol toxicity treated

A

With ethanol

Both metabolised by alcohol dehydrogenase

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2
Q

Alcohol is mainly absorbed by

A

The small intestine

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3
Q

Where is alcohol metabolised

A

~90% in the liver

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4
Q

How does alcohol cause ketoacidosis

A

By impairing oxidation and building up ketones

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5
Q

Alcohol inhibits ADH causing what?

A

Reduced water resorption and clearer urine

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6
Q

What kind of effect does acute alcohol ingestion have on the heart?

A

Negative inotropic effect

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7
Q

How much is one unit in ethanol?

A

10ml or 8 grams

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8
Q

Define hazardous drinking

A

Drinking that increases the risk of harmful consequences
14-35 units for women
14-50 units for men

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9
Q

Define harmful drinking

A

Drinking that causes mental of physical damage
35 for women
50 for men

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10
Q

Define alcohol dependence

A

A strong desire to drink alcohol and difficulties controlling it’s use

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11
Q

How many units per person (without non-drinkers) did 2017 alcohol sales total to?

A

24 units per week

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12
Q

What is the alcohol use disorders identification test (AUDIT)?

A

A 10 question harm screening tool from the WHO

A score above 20 means there is a possible dependence

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13
Q

What is the drug of choice for medically assisted detoxification?

A

Chlordiazepoxide

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14
Q

Complications of withdrawal

A

Seizures
Hallucinations
Derlirium tremens
Wernicke-Korsakoff Syndrome

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15
Q

Pharmacological treatments for relapse prevention

A

Acamprosate
Naltrexone
Disulfiram

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16
Q

Acamprosate

A

Acts on GABA and glutamate transmission to correct imbalances

17
Q

Naltrexone

A

Blocks opioid receptors, reduces the rewarding effects of the endorphin system

18
Q

Disulfiram

A

Inhibits acetaldehyde dehydrogenase to cause and unpleasant reaction to drinking alcohol
Low compliance

19
Q

What is the best objective marker for alcohol consumption data

A

Sales and mortality rates

20
Q

How much does alcohol harm cause the NHS per year?

A

3.5 billion pounds per year

21
Q

What damage can alcohol due to nerves and muscles?

A

Peripheral neuropathy
Compression neuropathy
Myopathy

22
Q

Wernicke syndrome is associated with

A

Occular dysfunction, ataxia and acute confusion

23
Q

Korsakoff syndrome is associated with

A

Profound anterograde amnesia

24
Q

Wernicke-Korsakoff syndrome is caused by

A

Thiamine (vitamin B1) deficiency

25
Q

Cardiomyopathy can be caused by

A

8-9 units a day for 5+ years

26
Q

Acute arrhythmias caused by alcohol are known as

A

Holiday heart syndrome

27
Q

Chronic arrhythmias caused by alcohol are known as

A

Long QT

Dilated cardiomyopathy

28
Q

What is the mortality of alcohol related hepatitis

A

~50%

29
Q

How many calories are there in alcohol?

A

7 cals per 1 gram

30
Q

How does alcohol increase the risk of nutritional deficiencies?

A

It can replace food intake and alter appetite
Decreases pancreatic and bile secretions
Damages the stomach lining so nutrient transport is limited
Decreases liver stores and increases fat

31
Q

Risk of drinking to fetus

A

1st trimester: risk of miscarriage and premature birth
Range of lifelong conditions
Alcohol in the blood stream = alcohol in breastmilk