CK040 - Prognosis Flashcards
1
Q
What is a ‘prognostic factor’ ?
A
A marker that predicts the prognosis of a patient –> so any measure that is associated with a subsequent endpoint
2
Q
When is a biomarker ‘prognostic’ ?
A
When it informs about an outcome INDEPENDENT of treatment received
3
Q
When is a biomarker ‘predictive’ ?
A
When the treatment effect is different for biomarker-positive patients compared to biomarker-negative patients
4
Q
What is the rule of thumb for sample size?
A
Minimum of 10 subjects/events per coefficient
5
Q
How to test the ‘discrimination’ of your prediction model?
A
Use the ‘c-statistic’ (also called the AUC if the test result is dichotomous)
