Citric Acid Cycle Flashcards
Reaction 1
In: Acetyl CoA + Oxaloacetate
Out: Citrate
Product: H2O–>CoASH(coenzyme A)
Enzyme: citrate synthase
Reaction 2
In: Citrate Out: Isocitrate Product: CoASH --> NAD+-->NADH Enzyme: Aconitase
Reaction 3
In: Isocitrate
Out: a(alpha)-ketoglutrate + CO2
Product: NAD+–>NADH
Enzyme: Isocitrate Dehydrogenase
Reaction 4
In: alpha-ketoglutrate + CO2 Out: succinyl CoA Product: CoASH--> NAD+-->NADH Enzyme: alpha-Ketogluterate dehydrogenase
Reaction 5
In: succinyl CoA Out: succinate Product: GDP +Pi-->GTP-->ATP -->CoASH Enzyme: Succinyl CoA synthetase
Reaction 6
In: succinate
Out: fumerate
Product: FAD–> FADH2
Enzyme: succinate dehydrogenase
Reaction 7
In: fumerate
Out: malate
Product: H20–>
Enzyme: fumerase
Reaction 8
In: malate
Out: oxaloacetate
Product: NAD+–>NADH
Enzyme: Malate dehydrogenase
Where
mitochondrial matrix
products
2CO2, 3NADH, 1FADH2, 1ATP
regulated steps
rxn 1: ATP, NADH, Succinyl CoA inhibit citrate synthase
ADP activates
rxn 3: ATP, NADH inhibit isocitrate dehydrogenase
ADP, Ca2+ activates isocitrate dehydrogenase
rxn 4: NADH, SuccCoA inhibit a-KG dehydrogenase
Ca2+, AMP activate a-KG dehydrogenase