Citric Acid Cycle Flashcards

1
Q

Reaction 1

A

In: Acetyl CoA + Oxaloacetate
Out: Citrate
Product: H2O–>CoASH(coenzyme A)
Enzyme: citrate synthase

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2
Q

Reaction 2

A
In: Citrate
Out: Isocitrate
Product: CoASH -->
               NAD+-->NADH
Enzyme: Aconitase
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3
Q

Reaction 3

A

In: Isocitrate
Out: a(alpha)-ketoglutrate + CO2
Product: NAD+–>NADH
Enzyme: Isocitrate Dehydrogenase

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4
Q

Reaction 4

A
In: alpha-ketoglutrate + CO2
Out: succinyl CoA
Product: CoASH-->
               NAD+-->NADH
Enzyme: alpha-Ketogluterate dehydrogenase
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5
Q

Reaction 5

A
In: succinyl CoA
Out: succinate
Product: GDP +Pi-->GTP-->ATP
                -->CoASH
Enzyme: Succinyl CoA synthetase
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6
Q

Reaction 6

A

In: succinate
Out: fumerate
Product: FAD–> FADH2
Enzyme: succinate dehydrogenase

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7
Q

Reaction 7

A

In: fumerate
Out: malate
Product: H20–>
Enzyme: fumerase

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8
Q

Reaction 8

A

In: malate
Out: oxaloacetate
Product: NAD+–>NADH
Enzyme: Malate dehydrogenase

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9
Q

Where

A

mitochondrial matrix

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10
Q

products

A

2CO2, 3NADH, 1FADH2, 1ATP

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11
Q

regulated steps

A

rxn 1: ATP, NADH, Succinyl CoA inhibit citrate synthase
ADP activates
rxn 3: ATP, NADH inhibit isocitrate dehydrogenase
ADP, Ca2+ activates isocitrate dehydrogenase
rxn 4: NADH, SuccCoA inhibit a-KG dehydrogenase
Ca2+, AMP activate a-KG dehydrogenase

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