Citric Acid Cycle

Question 1

Where in the cell does the Kreb’s cycle occur?

Answer 1

in the mitochondria

Question 2

Is Pyruvate Dehydrogenase part of Glycolysis or Kreb’s?

Answer 2

Neither. It is the link between the two

Question 3

What happens to the pyruvate formed in glycolysis?

Answer 3

1. crosses into mitochondria

2. is converted into Acetyl-CoA by pyr dH complex

Question 4

Is the conersion of pyr to acetyl-CoA reversible or irreversible?

Answer 4

irreversible

Question 5

What kind of linkage is formed between CoA and an acetyl group?

Answer 5

thioester linkage

Question 6

is the merging of oxa and the acetyl group (1st step of Kreb’s) reversible or irreversible?

Answer 6

irreversible

Question 7

What is the enzyme aconitase named after?

Answer 7

the cis-aconitate intermediate that occurs during the isomerization of citrate to isocitrate

Question 8

What is complex II from the respiratory chain also called in Kreb’s Cycle and where is it located?

Answer 8

Succinate dehydrogenase

Embedded in the inner mito membrane of the cell

Question 9

What is the only substance burned in the Kreb’s Cycle?

Answer 9

acetyl CoA

Question 10

Difference between synthase and synthatase

Answer 10

Synthase: synthesize something
Synthatase: synthesizing something and using an ATP

Question 11

What does it mean when we say that citrate is “prochiral?”

Answer 11

Means that each C has a different chemistry, despite its simmetry

Question 12

How many irreversible reactions does the Kreb’s Cycle have?

Answer 12

3

Question 13

Pyruvate dehydrogenase inhibitors

Answer 13

ATP, acetyl-CoA, and NADH

Question 14

Pyruvate dehydrogenase activators

Answer 14

AMP, CoA, NAD+, Ca2+

Question 15

what are Anapleurotic Reactions?

Answer 15

reaction used to replace Kreb’s intermediates that were used for other purposes. This is accomplished through non Kreb’s intermediates.
That way, oxa is regenerated and will not run out.

Question 16

How can a compound be burned into H2O and CO2?

Answer 16

first it must be converted into acetyl-CoA

Question 17

Purpose of the Glyoxylate Cycle?

Answer 17

for plants to convert fatty acids into sugar to survive and form first leaf. After this, they can survive with photosynthesis.

Question 18

During the glyoxylate cycle, 2 net acetyl groups converted into what?

Answer 18

one succinate

Question 19

Acronym for Kreb’s Cycle intermediates

Answer 19

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Oxaloacetate
Citrate
Isocitrate
alpha-Ketoglutamate
Succinyl-CoA
Succinate
Fumarate 
Malate

Question 20

Acronym for Kreb’s Cycle intermediates

Answer 20

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Oxaloacetate
Citrate
Isocitrate
alpha-Ketoglutamate
Succinyl-CoA
Succinate
Fumarate 
Malate