Citric Acid Cycle Flashcards
Upon entering the mitochondrion via active transport pyruvate is first converted to a compound called acetyl coenzyme or acetyl CoA
Acetyl Coenzyme
The junction between glycolysis and the citric acid cycle is accomplished by a multi-enzyme complex that catalyzes three reactions…
Pyruvate carboxyl group (-COO-)
Acetate
Coenzyme A (CoA)
Already fully oxidized and thus has little chemical energy is removed and given off as a molecule of CO2
First step
Pyruvate carboxyl group (-COO-)
Remaining two-carbon fragment is oxidized forming acetate
An enzyme transfers extracted electrons to NAD+ storing energy in the form of NADH
Acetate (ionized form of acetic acid)
Sulfur-containing compound derived from a B vitamin attached to the acetate by unstable bond that makes the acetyl group very reactive
Coenzyme A (CoA)
German British biologist physician and biochemist
Largely responsible for working out the pathway in the 1930’s
Hans Adolf Kreb
Cycle functions as a metabolic furnace that oxidizes organic fuel derived from pyruvate
Krebs Cycle
The formation of ATP from ADP and a phosphorylated intermediate
Amount of ATP that is generated by glycol is relatively low
Substrate-level phosphorylation
is a type of chemical reactions that involves a transfer of electrons between species
Redox Reactions
Krebs cycle number of process
8 step process
Krebs cycle takes place in the?
Matrix of Mitochondria under aerobic condition