CIS Lymphocyte Activation

Question 1

Hyper IgM Syndrome

Answer 1

Five types
X linked Genetic defect in CD40L

Inabillity for class switching

Prone to infections

Lack of B cells

Neutrophenia, failure to thrive
thrombocytopenia and anemia

Question 2

Why is IgG more protective Antibody

Answer 2

Important in neutralization
Opsoniztion
KIlling via NK cells
Activation of Complement

Found all over the body and is the most abundant

Question 3

Cyclosporin A

Answer 3

Graft rejection immunosuppressant
used after the transplant
inhibit host from killing donor cells

Question 4

Opportunistic Infections

Answer 4

Infections caused by pathogens that take advantage of weakened or lacking immune response

• Candida
• C. difficile
• Pneumocystis jiroveci
• Toxoplasma gondii
• cytomegalovirus

Question 5

Leprosy

Answer 5

chronic granulomatus disease

cutaneous lesions, neuropathic changes, and deformities

colonizes in macrophages and other most cells and multiplies within them

can only be eliminated by macrophages

Clinical symptoms vary depending on the type of immune response to the myobacterium

Question 6

Leprosy: Tuberculoid

Answer 6

Th1 response, high IL-2 and TNF-y and TNF-B

less severe less infectivity

Normal T cell response

Not as severe

Question 7

Leprosy: Lepromatous

Answer 7

Th2 response

way more severe and infective

much more IL-4 and IL-5 and IL-10 presence of cytokines

Low or absent T cell responsiveness

Question 8

Toxic Shock syndrome (TSS)

Answer 8

caused by the toxin of S. Aureus infection

super antigen that activates T cell in the absence of co simulators

can be grown in the Vagina and also is known to cause food poisoning

Fever Rash

edema hypertension and shock with multiple organ failures due to intravascular volume deletion

TNF-a and IL-1 lead to increase vascular permeabillity