CIS: ANS Pharmacology

Question 1

Parasympathetic NT and receptors

Answer 1

NT: Ach
Receptors: nAchR, mAchR

Question 2

Symphathetic NT and receptors

Answer 2

NT: NE > Epi
Receptors: alpha and beta receptors

Question 3

alpha-1 receptors

Answer 3

• stimulate contraction of all smooth muscle
• vasoconstriction
• sympathetic NS primary mode of controlling vascular tone

Question 4

Beta-2 receptors

Answer 4

relax smooth muscle (vasodilation)

Question 5

muscarinic receptors

Answer 5

-contract smooth muscle in a different intracellular signal than alpha-1R

Question 6

Key receptors on the hear that is responsible for increase HR and increase cardiac output

Answer 6

Beta-1 receptors

-increases the rate of contraction

Question 7

What is the effect of alpha adrenergic receptor (phenylephrine) infusion?

Answer 7

increase in mean blood pressure and decrease heart rate

Question 8

what drug blocks the decrease in HR

Answer 8

muscaranic AchR antagonist (atropine)

Question 9

Consequences of too much beta-2 in the system

Answer 9

activation of beta-1 receptors –> increase HR and CO

Question 10

Mechanism of Digoxin

Answer 10

• used in CHF
• inhibits Na/K pump, increase Ca inside the cell, increases force (cardiac glycoside=positive ionotropy)
• decreases HR = negative chronotropy

Question 11

Beta-1 antagonist mechanism

Answer 11

• decrease in force

- decrease rate of contraction