CIS

Question 1

how does Losartan help Marfan pts?

Answer 1

down regulates TGFbeta

Question 2

mutated fibrillin leads to not binding TGFbeta leads to what

Answer 2

extra growth, why they are tall

Question 3

What cancer is associated with Down syndrome

Answer 3

acute myeloid leukemia with megakaryocytic maturation

Question 4

meconium illeus

Answer 4

cystic fibrosis

Question 5

fetal hydrops with neck edeam, coarctation of the aorta, dysgenesis of the ovary, and horseshoe kidney

Answer 5

Turner syndrome

Question 6

tissue paper cytoplasm, Jewish, skeletal muscle, bone and spleen, no CNS

Answer 6

Gaucher disease type 1

Question 7

oligohydraminos, bilateral lung hypoplasia, multicystic dysplasia of kidneys

Answer 7

Potter’s sequence

Question 8

tumor around adrenal gland of kidney ddx

Answer 8

Wilms tumor vs neuroblastoma

Question 9

Homer-Wright Pseudorossettes

Answer 9

Neuroblastoma

Question 10

double minutes and deletion at chromosome 1p32

Answer 10

Nmyc oncogene highly amplified

Question 11

Nmyc amplification is

Answer 11

bad