CIS

Question 1

progression to mibc

Answer 1

54% within 5 years

Question 2

cis disease free at 5 years with bcg

Answer 2

Half of patient disease free at 5 years with BCG

1/3 at 10 years

Question 3

failure respond to bcg

Answer 3

50%

Question 4

progression responders vs non responders

Answer 4

Approximately 10-20% of complete responders eventually progress to muscle-invasive disease, compared with 66% of non-responders

Question 5

sylvester cis ma

Answer 5

9 randomised controlled trials involving 700 patients with NMIBC. Resulting in an absolute risk reduction of 20.5% and relative risk reduction of 59%. Therefore BCG is more effective than intravesical chemotherapy in CIS.

Question 6

overtreatment of cis with cystectomy

Answer 6

Tumour-specific survival rates after immediate RC for CIS are excellent, but as many as 40-50% of patients might be overtreated