Chemotherapy

Question 1

grossman swog group trial mvac

Answer 1

RC alone or 3 cycles of MVAC

ITT analysis, median survival 77 months vs 46 months

Question 2

Yin 2016 Oncologist

Five year survival

Answer 2

Three MA
1,596 patients inc Nordic I and II trials

8% absolute improvement in survival at five years with a number needed-to-treat of 12.5

Question 3

griffiths analysis NAC 10 yr survival rate

Answer 3

The updated analysis of a large randomised phase III trial with a median follow-up of eight years confirmed previous results and provided additional findings:

• 16% reduction in mortality risk

improvement in 10-year survival from 30% to 36% with neoadjuvant CMV; benefit with regard to distant metastases;