Circuit Defects Flashcards
1
Q
Discuss conventional treatments that restore the faulty circuitry involved in Parkinson’s disease
A
Restoration of dopamine deficits
L-dopa: DA precursor that can cross BBB- DA can’t
Mono-amine oxidase (MAO): COMT inhibitors that prevent the reuptake and breakdown of dopamine, used in combination with L-dopa
2
Q
Explain the role of alpha synuclein in Parkinson’s
A
Related to the loss of dopamine cells
Protein is normally degraded by chaperone mediated autophagy (CMA)
Upregulation of CMA could degrade overloaded alpha synuclein- new treatment option
3
Q
Deep brain stimulation of the ___________ of the _____________ can increase ____________ to relieve _______________.
A
Subthalamic nucleus
Basal ganglia
Dopamine production
Parkinson’s
