Chylomicrons

Question 0

Metabolism of chylomicron

Answer 0

Main site : adipose tissue and skeletal muscle
Half life in blood is about 1 hour
The enzyme lipoprotein lipase is located at the endothelial layer of capillaries of adipose tissue, muscle and heart but not in liver
Apo C II present in chylomicron activates the LPL
The LPL hydrolyze triglyceride present in chylomicrons into fatty acids and glycerol
Muscle or adipose tissue cells take up tje liberated fatty acids

Question 1

Synthesis of chylomicrons

Answer 1

Synthesis in the intestinal mucosal cells and secreted into the lacteals of lymphatic systems
They are rich in triglyceride
When the chylomicrons are synthesized by intestinal mucosal cell contain apo B 48 and apo A but apo C and apo E are added from HDL in blood during transport

Question 2

Post heparin lipolytic activity

Answer 2

Following injection of heparin the LPL is released from the tissues and lipemia is thus cleared this is called post heparin lipolytic activity
Lack of C II lead to decrease activity of LPL and consequent accumulation of chylomicron and VLDL in blood
Insulin icrease LpL activity

Question 3

Function of chylomicron

Answer 3

Chylomicrons are the transport form of dietary triglycerides from intestines to the adipose tissue for storage and heart or muscle for their energy needs