Churg-Strauss syndrome

Question 1

What is Churg-Strauss syndrome also known as?

Answer 1

Eosinophilic granulomatosis with polyangitis (EGPA)

Question 2

What type of condition is EGPA? Thus what serology may be positive?

Answer 2

ANCA associated small-medium vessel vasculitis
pANCA +ve in 60%

Question 3

What are the 3 stages of Churg-Strauss syndrome?

Answer 3

1. Allergy; many have hx of asthma/ allergic rhinitis
2. Eosinophilia
3. Vasculitis of small + medium vessels resulting in multi-organ damage: kidneys, lungs, digestive tract + heart

Question 4

What may a patient present with in the first stage? Why?

Answer 4

Nasal polyps
Inflammation of nasal passages can lead to development of polyps