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Pharmacology > Chunk > Flashcards

Chunk Flashcards

1
Q

Tricyclic antidepressants: Tertiary amines

A 
Amitriptyline
Clomipramine
Doxepin
imipramine
trimipramine
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2
Q

Tricyclic antidepressants: Secondary amines

A

nortriptyline
desipramine
protriptyline

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3
Q

SSRIs

A 
Fluoxetine
Fluvoxamine
Paroxetine
Sertraline
Citalopram
Escitalopram
Vilazodone
Vortioxetine
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4
Q

SSRIs first line treatment for what disorders?

A 
Depression
OCD
Panic disorder
Social phobia
PTSD
Premenstrual DD
GAD
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5
Q

SSRI with longest half life?

A

Fluoxetine (1-3 days)

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6
Q

SSRI with shortest half life?

A

Fluvoxamine (15 H)

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7
Q

SSRIs that DO NOT interact with CYP 450?

A

Citalopram

Escilatopram

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8
Q

Most activating SSRIs?

A

Fluoxetine

Sertraline

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9
Q

Most sedating SSRIs?

A

Paroxetine (+weight gain)

Fluvoxamine

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10
Q

Serotonin Syndrome clinical triad?

A

Cognitive effects
Neuromuscular dysfunction
Autonomic dysfunction

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11
Q

Serotonin syndrome drugs

A 
Cocaine
Dextromethorphan
Meperidine
SSRI
TCA
Trazodone
Venlafaxine
L dopamine
L tryptophan
MAOIs
Amphetamines
Lithium
MDMA
Triptans
Buspirone
LSD
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12
Q

SNRIs

A 
Main:
Duloxetine
Venlafaxine
Desvenlafaxine
Other:
Levomilnacipran
Milnacipran
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13
Q

NDRIs

A

Buproprion

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14
Q

Serotonin Receptor Antagonists

A

Trazodone
Mirtazapine
Nefazodone

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15
Q

MAOIs: non selective

A

Phenelzine

Tranylcypromine

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16
Q

MAOIs: MAO-B inhibitors

A

Selegiline Transdermal System

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17
Q

CYP 1A2 inhibitor

A

Fluvoxamine

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18
Q

CYP 2D6 inhibitors

A

Bupropion
Fluoxetine
Paroxetine

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19
Q

CYP 3A4 inhibitor

A

Nefazodone

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20
Q

Antidepressants that cause somnolence?

A

Mirtazapine
Paroxetine
Trazodone

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21
Q

Antidepressants that cause increase in energy?

A

Bupropion
SNRI
Fluoxetine
Sertraline

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22
Q

Antidepressants that can cause reduction in pain?

A

Duloxetine (Fibromyalgia/Neuropathic)
Venlafaxine (Fibromyalgia/Neuropathic)
Amitriptyline (Diabetic neuro)
Imipramine (Diabetic Neuro)

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23
Q

Augmentation to depression therapy?

A

Lithium
Thyroid stimulants
Atypical antipsychotis

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24
Q

Bipolar: Anticonvulsants?

A

Divalproex/Valproic acid
Carbamazepine
Lamotrigine
Topiramate

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25
Q

Bipolar: Benzodiazepines?

A

Lorazepam

Diazepam

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26
Q

Drugs causing parkinson’s symptoms?

A 
prochlorperazine
chlorpromazine
trifluoperazine
thioridazine
haloperidol
metoclopramide
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27
Q

Parkinsons: Dopamine agonists?

A

Non Selective:
Bromocriptine

Non Ergot:
Ropinirole
Pramipexole

D2 Selective:
Apomorphine

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28
Q

Parkinsons: Dopamine analogs?

A

levodopa/Carbidopa

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29
Q

Parkinsons: Muscarinic antagonists “anticholinergic”?

A

Benztropine

Trihexyphenidyl

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30
Q

Parkinsons: NDMA receptor inhibitor?

A

Amantadine

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31
Q

Parkinsons: Decreased catabolism: COMT inhibitors?

A

Tolcapone
Entacapone
Carbidopa/Levodopa/Entacapone

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32
Q

Parkinsons: Decreased Catabolism: MAOIs

A

Selegiline

Rasagiline

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33
Q

Drugs used to treat a broad range of seizure types?

A 
Carbamazepine
Felbamate
Lamotrigine
Levetiracetam
Oxcarbazepine
Phenytoin
Topiramate
Valproate
Zonisamide
34
Q

Drugs used primarily for focal onset seizures?

A 
Carbamazepine
Gabapentin
Lacosamide
Oxcarbazepine
Phenobarbital
Phenytoin
Pregabalin
Tiagabine
Vigabatrin
Valproate
35
Q

Absence seizure medications?

A

Ethosuximide

Valproate (Alt)

36
Q

Phenytoin non dose related adverse effects?

A

Sexual Dysfunction
Hirsutism
Gingival hyperplasia
Coarsening of facial features

37
Q

Phenytoin dose related adverse effects?

A

Nystagmus
Blurred/double vision
Thick tongue
Dizziness

38
Q

Prolonged febrile seizures may be treated with?

A

phenobarbital

diazepam

39
Q

Status epilepticus: Emergency medications?

A

Lorazepam
Diazepam
Midazolam

40
Q

Status Epilepticus: Urgent medications?

A

Fosphenytoin
Phenytoin
Phenobarbital

41
Q

Status epilepticus: Refractory medications?

A

Pentobarbital
Propofol
Midazolam

42
Q

Drugs that decrease effectiveness of Oral contraceptives, patch, ring, implant?

A 
Carbamazepine
Felbamate
lamotrigine
Oxcarbazepine
Phenobarbital
Phenytoin
Primidone
Topiramate
43
Q

High incidence of sexual dysfunction (Seizure meds)

A 
Carbamazepine
phenobarbital
phenytoin
pregabalin
topiramate
zonisamide
44
Q

Improved sexual functioning (Seizure meds)

A

Lamotrigine

Oxcarbazepine

45
Q

Decreased bone health (Seizure meds)

A 
Carbamazepine
Clonazepam
Phenobarbital
Phenytoin
Valproic acid
46
Q

Seizure meds with highest incidence of depression/suicide?

A 
levetiracetam
phenobarbital
primidone
tigabine
topiramate
vigabatrin
47
Q

Typical (First generation) Antipsychotics: Low potency

A

Chlorpromazine

Thioridazine

48
Q

Atypical (Second generation) antipsychotics

A 
Aripiprazole
Asenapine
Clozapine
Illoperidone
Lurasidone
Olanzapine
Paliperidone
Quetiapine
Risperidone
Ziprasidone
49
Q

Typical (First Generation) antipsychotics: High potency

A

Trifluoperazine
Fluphenazine
Haloperidol

50
Q

Antipsychotics for acute agitation and psychosis: Orally disintegrating tablets?

A

Risperidone

Olanzapine

51
Q

Antipsychotics for acute agitation and psychosis: Parenteral formulation

A

Ziprasidone

Olanzapine

52
Q

Antipsychotics for acute agitation and psychosis: Rapid tranquilization?

A 
Chlorpromazine
Fluphenazine
Haloperidol (Preferred)
Ziprasidone (Preferred)
Olanzapine (Preferred)
53
Q

Antipsychotics for acute agitation and psychosis: non compliant patients?

A

Haloperidol Decanoate
Fluphenazine Decanoate
Long acting risperidone (CONSTA)
Paliperidone

54
Q

Short acting barbiturates (Used for anesthesia)

A

Methohexital (C4)
Pentobarbital
Secobarbital
Amobarbital

55
Q

Short acting BZDs

A

Midazolam
Oxazepam
Triazolam

56
Q

Intermediate acting BZDs

A

alprazolam
Estazolam
Lorazepam
Temazepam

57
Q

Long acting BZD

A 
Chlordiazepoxide
Clonazepam
Diazepam
Flurazepam
Quazepam
58
Q

Clinical Use for BZD?

A 
Anxiolytic (Sedative)
Hypnotic(High Doses)
Muscle Relaxation
Anticonvulsant
Anesthesia/amnesia
59
Q

BZD indicated for alcohol withdrawal?

A

Oxazepam
Lorazepam
Chlordiazepoxide
DIazepam

60
Q

BZD indicated for insomnia?

A 
Triazolam (Induction)
Estazolam (Maintenance)
Temazepam (Maintain)
Flurazepam (Induce/maintain)
Quazepam (Induce/maintain)
61
Q

BZDs that are substrates of CYP3A4?

A

Alprazolam
Clonazepam
Temazepam

62
Q

Safest BZD for Geriatric populations?

A

Lorazepam
Oxazepam
Temazepam

63
Q

Sedating antidepressants?

A

Doxepin
Mirtazepine
Trazodone

64
Q

Insomnia: Sleep onset non BZD

A

Eszopiclone
Zaleplon
Zolpidem
Ramelteon

65
Q

Insomnia: Sleep maintenance non BZD?

A

Eszopiclone

Zolpidem CR

66
Q

Insomnia: Chronic non BZD?

A

Eszopiclone

Ramelteon

67
Q

Stimulants for ADHD

A

Amphetamines
Dextroamphetamine
Methylphenidate/Dexmethylphenidate
Lisdexamfetamine

68
Q

Non stimulants for ADHD

A

Atomoxetine
Clonidine XR
Guanfacine XR

69
Q

TCAs for ADHD?

A

Imipramine

Desipramine

70
Q

Obesity: Reduction of fat absorption?

A

Orlistat

71
Q

Obesity: Reduce appetite: Sympathomimetics?

A 
Benzphetamine
Diethylpropion
Phentermine
Phendimetrazine
Bupropion
72
Q

Obesity: Reduce appetite: Serotonergic?

A

Lorcaserin

Topiramate

73
Q

Obesity: Reduce appetite: Antidiabetic?

A

Liraglutide

Metformin

74
Q

Obesity: Combo?

A

Phentermine-topiramate

Bupropion-naltrexone

75
Q

Pre-anesthetic medications?

A 
Antacids
anticholinergics
antiemetics
antihistamines
BZD
Opioids
76
Q

General anesthetics: Inhales

A 
Desflurane
Halothane
Isoflurane
Nitrous Oxide
Sevoflurane
77
Q

General anesthetics: IV

A 
Barbituates
BZD
Dexmedetomidine
Etomidate
Ketamine
Opioids
Propofol
78
Q

Neuromuscular blockers

A 
Cisatracurium
Pancuronium
Rocuronium
Vercuronium
Succinylcholine
79
Q

Local Anesthetics

Esters

A 
Benzocaine
Chloroprocaine
Cocaine
Procaine
Tetracaine
80
Q

Local anesthetics

Amides

A 
Articaine
Bupivacaine
Dibucaine
Levobupivacaine
Lidocaine
Mepivacaine
Prilocaine
Ropivacaine
81
Q

Topical local anesthetics

A

Lidocaine 5% Patch
Lidocaine Prilocaine
TAC Solution
LET Gel

82
Q

Geriatric considerations for seizures? Carbamazepine? Phenytoin? Valproic Acid? Diazepam? Lamotrigine?

A 
Carbamazepine decreased clearance
Phenytoin decreased protein binding in renal failure
Valproic acid decreased protein binding
Diazepam increased half life
Lamotrigine decreased clearance

Pharmacology (2 decks)

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