Chronic Pancreatitis

Question 1

Cause of chronic pancreatits?

Answer 1

Progressive destruction of pancreatic parenchyma and its replacement w/ fibrosis

Question 2

Major cause of chronic panreatitis?

Answer 2

Alcoholism

Question 3

What is alcohol’s rolein pathogenesis of chronic pancreatitis

Answer 3

Alcohol is a pancreatic secretogogue. Increased pancreatic enzymes w/o increased fluid results in deposition of protein plugs

Question 4

Condition that devlops w/i the area b/w the head of the pancreas, the common bile duct and the duodenum?

Answer 4

Groove (paraduodenal) pancreatitis

Question 5

Pathogenesis of pancreatitis in cystic fibrosis?

Answer 5

B/c secretions in patients w/ CF are extremely viscid, plugs obstruct cystically distended pancreatic ducts, leading to chronic pancreatitis and eventually exocrine pancreatic insufficiency

Question 6

What causes most hereditary pancreatitis?

Answer 6

Increase in trypsin levels w/i pancreas due to autoactivation of trypsinogen

Question 7

What genes are typically mutated in hereditary pancreatitis?

Answer 7

Cationic trypsinogen gene and in the serine protease inhibitor gene

Question 8

What condition do almost have of patients w/ hereditary pancreatitis form?

Answer 8

Pancreatic ductal carcinoma

Question 9

What is the most common type of chronic pancreatitis?

Answer 9

Chronic calcifying pancreatitis