Chronic Pain Management Flashcards
NSAIDs (MOA)
Inhibition of Cyclooxygenase
Prostaglandin synthesis decreases
NSAIDs (Side Effects)
GI irritation/bleeding
Renal toxicity
Potential drug-drug interactions
Cardiovascular side effects (COX-2)
NSAIDs (Efficacy)
Nociceptive pain
Non-Opioid Analgesic (Efficacy)
Analgesic and antipyretic effects
No anti-inflammatory action
Non-Opioid Analgesic (MOA)
Inhibition of central prostaglandin synthesis
Non-Opioid Analgesic (Side effects)
Risk of toxic liver damage
Opioid Analgesic (Examples)
Weak: Tramadol, Codeine
Strong: Morphine, Oxycodone
Opioid Analgesic (Efficacy)
Nociceptive pain
Less effective in chronic states
Partially effective in neuropathic pain
Opioid Analgesic (MOA)
Activate the endogenous analgesic system.
Stimulate receptors in limbic system to eliminate the feeling of pain
Affect descending pathways that modulate pain perception
Reduce ascending pain signal transmission in the spinal cord
Opioid Analgesic (Side effects)
Nausea Vomiting Constipation Dizziness Vertigo Somnolence Dry skin, pruritis
TCAs (Efficacy)
Neuropathic pain
Complex regional pain
Tension headache
TCAs (MOA)
Inhibition of neuronal reuptake of noradrenaline and serotonin (5-HT)
TCAs (Side effects)
Constipation Dry mouth Somnolence Abnormalities in heart rhythm or rate Insomnia Increased appetite
Anticonvulsants (Efficacy)
Neuropathic pain
Anticonvulsants (MOA)
Gabapentin: binds to presynaptic voltage-dependent calcium channels
Pregabalin: interacts with special N-type calcium channels
Carbamazepine: blocks Na and Ca channels
