Chronic Obstructive Pulmonary Disease Quiz

Question 1

COPD is characterized how?

Answer 1

characterized by airflow obstruction that does not respond to bronchodilators

Question 2

Which of the following are true about Serpinal Variants? (choose all that apply)

• the major cause of COPD
• some are associated with reduced serum levels of alph-1-antitrypsin
• are rare
• have strong gene- environment- smoking interactions
• are associated with chronic bronchitis

Answer 2

• some are associated with reduced serum levels of alph-1-antitrypsin
• have strong gene- environment- smoking interactions

Question 3

Tobacco smoke promotes development of COPD by all of the following EXCEPT?

• inhibition of neutrophil elastase
• Recruitment of macrophages to the respiratory bronchioles
• Oxidation of alph-1-antitrypsin, directly and via H2O2 from macrophages, that results in inhibition of its antiproteolytic activity
• Activation of airway macrophages

Answer 3

inhibition of neutrophil elastase

Question 4

Differentiation of adult-onset asthma and COPD is what?

Answer 4

Complicated because some people may have combinations of asthma and emphysema and or chronic bronchitis

Question 5

Which of the following is NOT true about normal age related loss of lung function (FEV1)? (choose the incorrect answer)

• Can be accelerated by endotoxin exposure among pig farmers
• Can start as early as age 20
• Usually begins soon after graduation from college (i.e. about age 25)
• Never results in respiratory symptoms during the average life span

Answer 5

Never results in respiratory symptoms during the average life span