Chronic Lymphoproliferative DIsorders Flashcards
What is the most important chronic lymphoproliferative disorder?
chronic lymphocytic leukemia
Does chronic lymphoproliferative disorder have a long or short course
long - and indolent, but incurable, which is odd to say
WHat cells are high in CLL?
small, MATURE lymphocytes (they don’t even look neoplastic)
Are the lymphocytes in CLL B or T cells?
B cels
What marker do the B cells have in CLL and why is this weird?
CD5 - weird because that’s usually a T cell marker and is only present on B cells at a certain stage of devlopment
Why is infection common in CLL?
Because CLL is associated with hypogammaglobulinemia (we don’t know why)
So in terms of immunophenotypeing for CLL, cells will be positive for what markers and negative for what marker?
positive for CD20 (B cell) and that CD5 mentioned earlier
negative for TdT (not blasts)
In general, is treatment for CLL liberal or conservative?
conservative - often treatment is more difficult on the body than the leukemia is, so only treat if symptoms present
What are some of the factors that affect prognosis in CLL?
WBC (lower is better)
adenopathy (less is better)
Bone marrow involvement (less is better)
WHat’s the mean survival of CLL and what’s the usual cause of death?
9 years - infection
For hairy cell leukemia, do you get splenomegaly or lymphadenopathy?
just splenomegaly (which is somewhat unusual)
What sort of anemia do you get with hairy cell leukemia?
pancytopenia
What stain can you use to look at hairy cells?
TRAP
Hairy cell leukemia is most common in what group of people?
men (5:1) over 40 yrs old
For hairy cell leukemia, if you don’t have pancytopenia, you will generally always have what?
monocytopenia (not sure why)
What does immunophenotyping show in hairy cell leukemia?
B cell markers (CD20 and CD19), but no CD5 - that was CLL
WHat’s the treatment and prognosis for hairy cell eukemia?
chemotherapy - really good (usually over 10 years)
What’s the appearance of bone marrow in hairy cell leukemia?
chicken wire - because the cells look so far apart due to the excess cytoplasm
What cells are high in prolymphocytic leukemia?
prolymphocytes (duh) - youll be able to pick them out because they have dense chromatin and nucleoli
Is prolymphocytic leukemia more or less aggressive than CLL?
more aggressive
What cells are high in large granulated lymphocyte leukemias?
large granulated T lymphocytes - they look really weird
Why are infections so common in large granulated lymphocyte leukemia?
because you get neutropenia for some reason
Is granulated lymphocyte leukemia a long or short course?
long - basically just considered a chronic disease
