Chronic Leukemia

Question 1

CLL

Answer 1

Proliferation of Naive B-Cells
CD-5 - normally on T-Cell
CD-20
Increased Lymphocytes - Lymph Nodes
Generalized Lymphadenopathy = Small Lymphocytic Lymphoma (SLL)
Smudge Cells ("splattered cell")
Hypogammaglobulinemia - infection
Autoimmune Hemolytic Anemia - ab-RBCs

Question 2

Hairy Cell Leukemia

Answer 2

Mature B Cells
Hairy Cytoplasmic Processes
TRAP Positive - Tartrate Resistant Acid Phosphotase
Splenomegaly of Red Pulp
Dry tap with Bone Marrow Aspiration
Absent Lymphoadenopathy
Good Response to 2-CDA - Adenosine Deaminase Inhibitor

Question 3

ATLL

Answer 3

CD4 TCell proliferation Associated with HTLV-1
Rash**, Generalized LAD and HSM
Lytic Bone Lesions with Hypercalcemia

Question 4

Mycosis Fungoides

Answer 4

Proliferation of Mature CD4 T-cells
Skin rash, plaques and nodules
Pautrier microabscesses - aggregates of Tcells in epidermis.
Sezary Syndrome - cerebriform nuclei spread to involve blood