Acute Leukemia Flashcards
1
Q
AML
A
MPO Positive (Auer Rod) Crystals
Punched out Nucleolus
Older Adults ~55
2
Q
ALL
A
tDt Positive (DNA pol for lymphoblast) Arises in Children - Down Syndrome
3
Q
B-ALL
A
CD-10, 19, 20
Prophylaxis to Scrotum and CSF
Ph+ ALL or 9;22 poor prognosis; adults
12;21 is good prognosis; kids
4
Q
T-ALL
A
CD-2 to CD-8; NOT CD-10
Presents as Thymic Mass; Teenager
“Acute Lymphoblastic Lymphoma”
5
Q
Acute Promyelocytic Leukemia
15;17 translocation
AML Subtype
A
Retanoic Acid Receptor disrupted
Promyeloctes contain Auer Rods - DIC
ATRA - All TransRetanoic Acid (VitA Deriv) is curative.
6
Q
Acute Monocytic Anemia
A
Proliferation of Monoblasts infiltrating Gums.
Lack MPO
7
Q
Acute Megakaryoblastic Leukemia
A
Proliferation of Megakaryoblasts, Associated with Down Syndrome
Lack MPO
History of exposure to aklylating agents or radiation therapy. Develop from Myelodysplastic Syndrome.
