chronic kidney disease

Question 1

chronic allograft nephropathy immunological factors

Answer 1

poor HLA matching and presence of HLA alloantibodies

sub optimal immunosupression and or non compliance of patient

these both cause
acute rejection incidents

Question 2

chronic allograft nephropathy non immunological factors

Answer 2

delayed graft function caused by 1. older donor/ poor graft quality 2. cause of death injury , preservation injury , ischaemic injury

hypertension
hyperlipidaemia
toxic effects of immunosupressents ciclosporin and tacrolimus

Question 3

Important tests to perform prior to transplant

Answer 3

• HLA type of the recipient
• HLA type of the donor
• Screen patient for presence of preforms HLA antibodies (every 3 months when patient is on transplant list)
• Crossmatch patient and donor prior to transplant to ensure negative result i.e. no reactions.