Chronic Inflammation & Wound Healing

Question 1

Which of the following is FALSE?

a) Autoimmune disease involves an immune reaction against own tissues.
b) Allergic disease is an exaggerated response against common environmental substances.
c) Hypersensitive immune reactions have no useful purpose.
d) Hypersensitive immune reactions involve only chronic inflammation.

Answer 1

d) Hypersensitive immune reactions can be acute or chronic or mixed.

Question 2

There are two main pathways of macrophage activation, classical and alternative. Which is TRUE regarding the alternative pathway.

a) involves M1 macrophages
b) induced by cytokines other than IFN-gamma such as IL-4, IL-13
c) induced by microbial products
d) produce NO and ROS which up regulate lysosomal enzymes

Answer 2

b)

Question 3

Which of the following is FALSE?

a) TH1 cells produce cytokine IFN-gamma, which activates macrophages via the classical pathway.
b) TH2 cells secrete IL-17 (& other cytokines), which induces secretion of chemokines to recruit neutrophils & monocytes.
c) TH2 cells are involved in defense against helminthic parasites/allergic inflammation.
d) TH17 cells are involved in defense against many bacteria/viral infections & autoimmune diseases.

Answer 3

b) TH17 cells secrete IL-17 (& other cytokines), which induces secretion of chemokines to recruit neutrophils & monocytes.

Question 4

Which acute phase protein is most involved with regulating iron?

a) C-reactive protein (CRP)
b) fibrinogen
c) serum amyloid A (SAA)
d) hepcidin

Answer 4

d)

Question 5

Which of the following is TRUE?

a) Labile tissues have limited capacity to regenerate after injury.
b) Stable tissues have minimal proliferative activity in normal state, but capable of dividing in response to injury/loss.
c) Permanent tissues include hematopoietic cells in bone marrow, columnar epithelia, and surface epithelia.

Answer 5

b)