Chronic Inflammation Flashcards
What is another term for Chronic inflammation and what cell type is mostly present?
Modulated
Macrophage
Name 2 mononuclear cells
Lymphocytes and macrophages
When does it develop?
- without acute - TB
- Alongside Acute-Bacterial Infection
- After Acute
What are Macrophages in the blood and when are they called that?
Monocytes in blood
Macrophages in the tissue
What new tissue forms?
Granulation tissue
Difference between Macrophages and neutrophils?
Macrophages circulate in blood for 6 days and can replicate whilst neutrophils die after a few days and are end cells
Neutrophil functions:
Phagocytosis Anti presentation Activate other cells by cytokines Inducing fibrous Inducing Fever- Acute Phase Reaction - Cachexia
T and B Lymphocytes function
Process Antigens
Secreting Antibodies - B
Secreting Cytokines
Killer cells by Natural killer cells
Eosinophils
Attack parasites and allergic reactions
(Myo)Fibroblast function
Chemotaxis
produce CT such as collagen Glucoaminoglycans and elastin. Myo can contract
What are giant cells and name 3 .
Fused Macrophages with multiple Nuclei
Langhans
Foreign Body
Touton Giant cells
Describe appearance of Langhans
Nuclei around edges of cell and seen in TB
Describe appearance of Foreign Body type
Randomly arranged- Body phagocytosed so seen in cell or on surface
Describe appearance of Touton
Ring toward the center. Lesion where they is high lipid content. Xanthomas and Fat Necrosis. Foam Cells
Unwanted Effects of acute inflammation
Fibrosis- impair function
Atrophy
Tissue destruction
Granulomatous inflammation
Occurs with hard to eliminate particles
What are Epithelioid cells
Modified macrophages which look like Epithelial tissue
What do Foreign Body granulomas contain ?
Macrophages , FB gaint cells, Epithelioid cells and fibroblasts
Non antigenic material - Surgical thread
What do Hypersensitive or immune granulomas Contain?
Macrophages, L giant Cells, Epithelioid cells , Fibroblasts
Insoluble but antigenic particles
They can occupy parachymal space .
What is Chronic Cholecyctitis?
Obstruction by gall stones leads to fibrosis of Gall Bladder wall
What is Ulcerative Colitis ?
Superficial Bleeding and inflammation in the Colon rectum
What are the causes of Cirrhosis
Chronic viral hepatitis (hepatitis B and C)
Fat accumulating in the liver (nonalcoholic fatty liver disease)
