chronic inflammation Flashcards
1
Q
chronic inflammation
A
response of prolonged duration in which inflammation + tissue injury + attemppts at repair all coexist, in varying conditions
2
Q
causes of CI
A
- source of infection persists
- prolonged exposure to toxic agent
- hypersensitivity decreases
- untreated acute inflammation
3
Q
where are macrophages derived from?
A
immature myeloid progenitor cells in bone marrow
4
Q
macrophages are differentiated from…?
A
monocytes in blood
5
Q
M1 macrophages
A
- inhibit cell proliferation
- causes tissue damage
- pro inflammatory
- functions as immune monitor
6
Q
M2 macrophages
A
- promotes cell proliferation
- promotes tissue repair
- anti-inflammatory
7
Q
resident macrophage of liver…
A
kupffer cells
8
Q
resident macrophage of CNS…
A
microglial cells
9
Q
resident macrophage of lungs…
A
alveolar macrophages
10
Q
resident macrophage of spleen + lymph nodes…
A
sinus histocytes
11
Q
roles of macrophages
A
- phagocytosis
- initiates tissue repair
- secretes chemokines
- release growth factors
- releases proteases
- presents antigen to T cells
12
Q
plasma cells are differentiated…
A
B - lymphocytes
13
Q
plasma cells originate from? + function
A
- originate in bone marrow
- secrete large quantities of antibodies
14
Q
plasma cells cancer
A
multiple myeloma
15
Q
plasma cells have eccentric nuclei with…
A
heterochromatin in cartwheels
