Chronic Heart Failure Flashcards

0
Q

Primary Causes Heart Failure

A

Failure of heart muscle or Failure of heart valves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Heart Failure Definition

A

Failure of the heart as a pump to meet the circulatory needs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Types Heart Failure

A

Acute - Post MI Chronic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Secondary/ Principle causes heart failure (3)

A

HYPERTENSION - Hypertrophy increasing cardiac work IHD - Impaired muscle function CARDIOMYOPATHIES - Alcohol, viral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Heart Failure Precipitants (4)

A

Pregnancy Anaemia Hyper/ hypo- thyroidism Fluid retaining drugs e.g. Glucocorticoids; NSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Heart Failure, neurohormonal adaptation - events (4)

A

Activation SNS Activation RAAS Activation ADH Activation ANP (atrial natriuretic peptide - promote sodium loss)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Heart failure, neurohormonal adaptation - consequences (5)

A

Increased after load Increased circulating volume (increased preload and after load) Increased resistance - will lead to impaired renal function, more salt/ water retention with further activation of RAAS Neurohormonal adaptation –> myocyte dysfunction Vicious circle –> further impairs pump activity of the heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

LEFT-SIDED FAILURE - Secondary cause & Consequence

A

Often secondary to hypertension Left ventricle impaired/ poor output leads to increase in ATRIAL/ PULMONARY VENOUS pressure with PULMONARY OEDEMA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

RIGHT-SIDED FAILURE - Causes (2)

A

Right ventricular output fails Due to Lung disease (cor pulmonale) Pulmonary valvular stenosis (valve between RV & Pulmonary aa)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

BIVENTRICULAR FAILURE - Causes (2)

A

Both chambers affected Disease (e.g. IHD) has affected both ventricles LV failure leads to pulmonary congestion, which may lead to RV failure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Heart Failure - Signs & Symptoms (6)

A

Fatigue, listless Poor exercise tolerance (determines grade) Cold peripheries Low blood pressure? Reduced urine flow Weight loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

LVF Signs and Symptoms

A

PULMONARY OEDEMA Dyspnoea - with a sensation of drowning (‘cardiac asthma’) Cough? Orthopnoea - breathlessness lying, relieved by sitting up (nocturnal?) Inspiratory crepitations on auscultation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

RVF Signs and Symptoms

A

Raised venous pressure Increased JVP Enlarged liver Oedema - ankles; if lying flat rises to thighs/ abdomen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Heart failure Diagnosis

A

Symptoms & Examination Confirmed by echocardiogram –> ejection fraction s lines (lines possibly due to lympathetic distension)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

AF Cause

A

LV/ Valve failure leading to increased pressure in the left atrium leading to distension which ends of atrial fibrillation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is AF?

A

Stasis of blood and stagnation leading to THROMBI which may dislodge and move to cerebral circulation (risk TIA). Need prophylaxis against THROMBOEMBOLISM: warfarin/ aspirin.

16
Q

Heart failure treatment goals (6)

A

Identify/ treat CAUSE - valvular disease, IHD Reduce cardiac WORKLOAD Increase cardiac OUTPUT Counteract MALADAPTATION Relieve SYMPTOMS Prolong QUALITY OF LIFE - reduce hospitalisation

17
Q

Principles of pharmacological management of heart failure (4)

A

Stage dependent All patients with LV systolic dysfunction should receive ACEI All patient with oedema should receive a DIURETIC BETA-BLOCKERS now recognised as having an important role and should be used first line in moderate / stable heart failure

18
Q

ACEIs for heart failure

A

First line Prolong life

19
Q

Heart failure ACEIs - Action & Examples

A

E.g. Enalapril, lisinopril, ramipril Reduce arterial and venous vasoconstriction - reduce after and pre load Reduce salt/ water retention, hence reduce circulating volume Inhibit RAAS: Oppose neurohormonal adaptation May prevent cardiac remodelling

20
Q

How to use ACEIs in heart failure (4)

A

Low dose, then titrate upwards, may exceed licensed max dose Do NOT use with NSAIDs Monitor urea/ creatinine/ K+ before and during treatment Avoid in hypotension: systolic <100 mmHg

21
Q

Heart Failure ACEIs - WARNINGS

A

May cause severe hypotension - withdraw diuretic therapy for a few days before, and give at night. May cause deterioration of renal function in pre-existing renal disease

22
Q

AT1R Antagonists - Action & Examples &

A

Oppose action of A2 at AT1 receptor E.g. Candesartan, valsartan, losartan Equally as effective as ACEIs but don’t cause bradykinin cough

23
Q

Diuretic use in Heart failure

A

Mainstay of therapy, used when there is oedema (ankle/ pulmonary) Thiazides (bendroflumethiazide) - used in mild failure or in the elderly Loop diuretics (furosemide) - especially used in pulmonary oedema, may be given I.V. for rapid relief via vasodilatation

24
Q

Heart failure, Diuretic effects & action

A

Cause reduction in circulating volume - reduce pre load and after load Also cause VENODILATATION - reduce preload

25
Q

Heart failure, Diuretics - caution

A

Thiazides/ loop diuretics may cause hypokalaemia, though this is less of a problem if they are used WITH ACEIs.

26
Q

Beta blockers - role in heart failure & examples

A

Used to be contraindicated in CHF Now Central role: Reduce disease progression Reduce symptoms and mortality Used in STABLE, MODERATE FAILURE Metoprolol. BISOPROLOL. Nebivolol. Carvedilol (also alpha blocker/ antioxidant).

27
Q

Heart failure. Beta blocker action (4)

A

Reduce sympathetic stimulation, heart rate, O2 consumption Anti-arrhythmic activity reduces sudden death (also control rate in AF) Oppose neurohormonal activation (which leads to myocyte dysfunction) Especially useful in failure associated with ISCHAEMIA

28
Q

How to use beta blockers in heart failure

A

Start with low dose under supervision Then work up Symptoms may get worse at first May be appropriate in concurrent COPD if used with caution

29
Q

SPIRINOLACTONE - effects & use in heart failure

A

Aldosterone receptor antagonist Inhibits aldosterone effects on heart (fibrosis which stiffens heart) Effective agent which reverses LV HYPERTROPHY Low dose 25mg (non diuretic dose) reduces mortality by 35%

30
Q

Heart failure, DIGOXIN activity (3)

A

Positive inotrope by inhibiting Na+/K+ ATPase –> Na+ accumulates in myocytes –> exchanged with Ca2+ leading to increased contractility Impairs AV conduction and increases vagal activity (via CNS) This heart block and bradycardia is beneficial in heart failure with AF! [NB. Digoxin contra-indicated in concurrent heart block or bradycardia]

31
Q

How to use Digoxin in heart failure

A

Generally reserved for heart failure with AF (or when other treatments fail to control condition) Titrate dose to ensure ventricular rate does not fall below 60bpm as this indicates toxicity.

32
Q

Heart Failure Patient monitoring - RENAL FUNCTION (5)

A

Patients often elderly and renal function (GFR) may be impaired Important for drug handling - dose of digoxin is reduced in renal impairment (as digoxin is 2/3 renally excreted) Thiazides are INEFFECTIVE in renal failure ACEIs - used with care in mild-moderate failure, RF monitored. ACEIs - contraindicated in renovascular disease (renal artery stenosis - when BP and renal perfusion are maintained by high levels of renin)

33
Q

Heart Failure Patient Monitoring - POTASSIUM

A

Hypokalaemia is a major problem Side effect of thiazides/ loop diuretics Enhances digoxin effects (digoxin competes with K+ for pump site) Serious possibility of hyperkalaemia with ACEI if used with a K+ sparing diuretic

34
Q

Heart Failure Patient Monitoring - DIGOXIN TOXICITY

A

Major problem Narrow T.I. SEs: Anorexia, nausea (suggest too high dose), visual disturbances, diarrhoea Digoxin in AF, monitor pulse (>60bpm)

35
Q

Treatment Algorithm - Evidence of LV dysfunction?

A