Chronic Granulomatous Disease (CGD) Flashcards
1
Q
What is caused in CGD?
A
Extensive inflammatory reactions
-nodes with purulent material leaking out
2
Q
What are common features of CGD?
A
Aphthous ulcers
Inflammation of nares
3
Q
Where can Granulomas become obstructive in CGD?
A
Lungs
GI tract
4
Q
What odd combination of infections is seen in CGD?
A
Staphylococcus
Burkholderia
Nocardia
Aspergillus
5
Q
How do you test for CGD?
A
Abnormal Nitroblue Tetrazolium test or DHR test
-detects respiratory burst that produces hydrogen peroxide
6
Q
What is absent or deficient in CGD?
A
NADPH Oxidase
-generates superoxide
