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USMLE Step 2: Allergy and Immunology > Angioedema > Flashcards

Angioedema Flashcards

1
Q

What is Angioedema?

A

Sudden swelling of the face, tongue, eyes and airway

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2
Q

What is the onset of Angioedema associated with?

A

minor physical trauma

ACE-Inhibitor use

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3
Q

What is a common underlying cause of Angioedema?

A

Deficiency of C1 Esterase Inhibitor

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4
Q

What are the best initial tests for Angioedema?

A

Decreased C2 and C4

Deficiency of C1 esterase Inhibitor

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5
Q

What are the treatment options for Angioedema?

A

Ensure Airway
Fresh Frozen Plasma
Ecallantide
Icatibant
Epinephrine
Antihistamines
Steroids
C1 Esterase Inhibitor Concentrate

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6
Q

What is the treatment for Acute Angioedema?

A

Fresh frozen plasma
Ecallantide
Icatibant

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7
Q

What is the Mechanism of Ecallantide?

A

Kallikrein Inhibitor

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8
Q

What is the mechanism of Icatibant?

A

Bradykinin B2-Receptor antagonist

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9
Q

How do you treat Urticaria and Early respiratory compromise in Angioedema?

A

Epinephrine
Antihistamines
Steroids

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10
Q

How do you treat Hereditary Angioedema?

A

C1 Esterase Inhibitor Concentrate

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11
Q

What is the mechanism of Lanadelumab

A

Antibody against Kallikrein

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12
Q

What are the prophylactic options for Surgical and Dental Procedures in Angioedema?

A

Antifibrinolytics
Androgens
Infusion of C1 Esterase Inhibitor

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13
Q

What Antifibrinolytic is used for Prophylaxis in Angioedema?

A

Tranexamic Acid

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14
Q

How does Tranexamic Acid work?

A

Decreases C1 Protein
-decreases production of bradykinin

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USMLE Step 2: Allergy and Immunology (15 decks)

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