Chronic Disease Flashcards

1
Q

Chronic Disease

A

Develop slowly and persists for a long period of time.
Start and are undetected in early adulthood or even childhood.
Once diagnosed, impossible to completely cure most chronic diseases.
Non-communicable.

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2
Q

Types of Diabetes

A

Type 1
Type 2
Gestational

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3
Q

Type 1 Diabetes

A

Usually diagnosed in childhood.
Occurs when the pancreas is unable to produce insulin.
Insulin is a hormone that controls the amount of glucose in the blood.
-glucose circulates in the blood and overabundance does damage
-more prone to infections because nutrients and oxygen not delivered where it needs to go
Approximately 10% of people with diabetes have type 1, and it’s decreasing.

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4
Q

Type 2 Diabetes

A

90% of cases.
The pancreas does not produce enough insulin or when the body does not effectively use the insulin that is produced.
-glucose builds up in your blood instead of being used for energy (called hyperglycemia).
-to use glucose your body needs insulin.
Usually develops in adulthood, although increasing numbers of children are being diagnosed.

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5
Q

Gestational Diabetes

A

A temporary condition that occurs during pregnancy.
It affects approximately 2-4% of all pregnancies.
Involves an increased risk of developing diabetes for both mother and child if not managed correctly.

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6
Q

Prevalence of Diabetes

A

More than 9 million Canadians have diabetes (Canadian population - 36 million).
Type 1 remaining stable.
Number of people with type 2 increasing dramatically due to the population aging, obesity rates rising, and Canadians lifestyles becoming increasingly sedentary.

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7
Q

Signs and Symptoms of Diabetes

A

The 3 P’s:
1) unusal thirst (polydipsia)
2) frequent urination (polyuria)
3) intense hunger (polyphagia)
Weight change.
Extreme fatigue or lack of energy.
Blurred vision.
Frequent or recurring infections.
Cuts and bruises that are slow to heal.
Tingling or numbness in the hands or feet.
Trouble getting or maintaining an erection.

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8
Q

The Personal Cost of Diabetes

A

Reduced quality of life and the increased likelihood of complications such as heart disease, stroke, kidney disease, blindness, amputation, and erectile dysfunction.
About 80% of people with diabetes will die as a result of heart disease or stroke.
Canadian adults with diabetes are twice as likely to die prematurely, compared to people without.

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9
Q

The Financial Cost of Diabetes

A

People with diabetes incur medical costs that are 3-4 times higher than those without diabetes.
As of 2020, it was estimated that diabetes cost Canadian healthcare system $16.9 billion a year.

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10
Q

Diabetic Neuropathy

A

About half the people with diabetes have diabetic neuropathy which can result in loss of sensation of the limbs.
Diabetes is a common cause of impotence in men.
Nerve damage and poor circulation to the limbs cause tissue damage in the extremities, especially the foot, which can lead to ulceration.
Diabetes is the leading cause of nontraumatic amputation of lower limbs.

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11
Q

Diabetic Retinopathy

A

Diabetic retinopathy results from damage to the small blood vessels in the eye and is the leading cause of incident blindness in adults age 20-74 years.
On average, about 2% of people with diabetes go blind, and 10% have vision problems after 15 years of diabetes.

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12
Q

Treatment of Diabetes

A

The evidence is clear that insulin sensitivity is improved while Type 2 diabetes is prevents or delayed in most people when they lose body fat.
An increase in moderate to vigorous physical activity can impact change even when they don’t lose much weight.
Nonetheless, drugs that regulate glucose are often needed in the treatment of people with type 2 diabetes.
-either reduce glucose output or reduce insulin resistance.

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13
Q

Exercise and Diabetes

A

Indian physicians were to first to recommend exercise for diabetes around 600 BC.
Greco-Roman physicians were recommending it around the year 1000.
Then we moved to treating it with bed rest, and high sugar and high starch foods.
Only about 15 years ago did we start to recommend exercise again as a serious treatment and preventative medicine for type 2 diabetes.

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14
Q

Cardiovascular Disease

A

Broad term referring to any disease that has to do with the heart or blood vessels.

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15
Q

Coronary Heart Disease vs Cardiovascular Disease

A

Cardiovascular disease a broad term for any disease that occurs in cardiovascular system.
Coronary heart disease is a disease in which a waxy substance called plaque builds up inside the coronary arteries.

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16
Q

Coronary Heart Disease (CHD)

A

Is a disease in which a waxy substance called plaque builds up inside the coronary arteries.
These arteries supply oxygen-rich blood to your heart muscle.
Over time plaque can harden or rupture.
-hardened plaque narrows the coronary arteries and reduces the flow of oxygen rich blood to the heart.
-if plaque ruptures, a blood clot can form and when large enough can block blood flow through a coronary artery or can harden and narrow the coronary arteries.
If the flow of oxygen-rich blood to your heart muscle is reduced or blocked, angina (large plaques) or myocardial infarction (ie. heart attack) can occur.
Can weaken heart muscle and lead to heart failure and arrhythmias.

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17
Q

Atherosclerosis

A

When plaque builds up in the arteries.
Can affect any artery in the body, it’s only CHD when it affects the arteries feeding the heart.

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18
Q

Heart Failure

A

Condition where your heart can’t pump enough blood to meet your body’s needs.
Arrhythmias are problems with the rate or rhythm of the heart beat.

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19
Q

Risk Factors for CHD

A

Genetic susceptibility
Male sex
Age
Elevated serum cholesterol (total amount of cholesterol found in your blood).
Low levels of HDL
Smoking
High blood pressure
Obesity
Diabetes
Physical inactivity

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20
Q

Signs and Symptoms of CHD

A

May have no symptoms but still have it, and as it gets more severe the symptoms will develop.
Pressure or tightness in chest (brought on by exercise or stress) and ceases shortly after activity is done.
Shortness of breath and extreme fatigue following physical exertion.
Heart attack (chest pain, shortness of breath, women may feel no chest pain but experience shortness of breath, dizziness, cold sweats, fatigue, etc.)

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21
Q

Exercise and CHD

A

Exercise adaptations include lowered blood cholesterol and triglycerides which reduce the risk of atherosclerotic plaques.
Exercise increases HDL
-good cholesterol that removes other types from the blood stream.
Another common adaptation is lowering heart rate and blood pressure and these regulate oxygen demand in the heart.
More efficient oxygen delivery and utilization.
Autopsy studies…
-physically active men who had atherosclerosis/plaque build-up still had large lumens (open space in artery).
-monkeys fed large amounts of high fat and cholesterol diets but lots of physical activity had healthier arteries than the monkeys who did not exercise.

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22
Q

Hypertension

A

High blood pressure.
Six million Canadian adults, or one in five, have high blood pressure, representing 19% of the adult populations.
Hypertension is the most common reason to visit a doctor.
Hypertension is the number one reason for taking medication.

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23
Q

Risk Factors for Hypertension

A

Overweight/Obesity
Physical inactivity
Using tobacco
Age
Too much salt (sodium) in your diet.
Too little potassium in your diet
Too little vitamin D in your diet
Drinking too much alcohol
Stress
Certain chronic conditions

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24
Q

Overweight/Obesity vs Hypertension

A

The more you weight the more blood you need to supply oxygen and nutrients to your tissues.
As the volume of blood circulated through your blood vessels increases, so does the pressure on your artery walls.

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25
Q

Physical inactivity vs Hypertension

A

People who are inactive tend to have higher heart rates
The higher your heart rate, the harder your heart must work with each contraction and the stronger the force on your arteries.
The lack of physical activity also increases the risk of being overweight

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26
Q

Using tobacco vs Hypertension

A

Not only does smoking or chewing tobacco immediately raise your blood pressure temporarily, but the chemicals in tobaccos can damage the lining of your artery walls
Can cause your arteries to narrow, increasing your blood pressure

27
Q

Too much salt (sodium) in your diet vs Hypertension

A

Too much sodium in your diet can cause your body to retain fluid which increases blood pressure.

28
Q

Too little potassium in your diet vs Hypertension

A

Potassium helps balance the amount of sodium in your cells
If you don’t get enough or retain enough, you may accumulate too much sodium in your blood.

29
Q

Too little vitamin D in your diet vs Hypertension

A

It’s uncertain if having too little vitamin D in your diet can lead to high blood pressure
May affect an enzyme produced by your kidneys that affects your blood pressure

30
Q

Drinking too much alcohol vs Hypertension

A

Over time, heavy drinking can damage your heart
Having more than two drinks a day can rise your blood pressure

31
Q

Stress vs Hypertension

A

High levels of stress can lead to a temporary, but dramatic, increase in blood pressure
If try to relax by eating more, using tobacco, or drinking alcohol, you may only increase problems with high blood pressure

32
Q

Certain Chronics Conditions vs Hypertension

A

Certain chronic conditions may increase your risk of high blood pressure, including high cholesterol, diabetes, kidney disease, and sleep apnea

33
Q

Blood Pressure

A

Measure of the pressure of blood against arteries.
Systolic and diastolic components.

34
Q

Systolic Component

A

Measures the amount of pressure that blood exerts on arteries and vessels while the heart is beating.

35
Q

Diastolic Component

A

Measures the pressure that is exerted on the walls of the arteries in between heart beats when the heart is relaxed.

36
Q

Systolic/Diastolic

A

Normal = 120/80 mmHg
Pre-hypertension = 120-139/80-90 mmHg
Stage 1 hypertension = 140-149/90-99 mmHg
Stage 2 hypertension = greater than 160/100 mmHg

37
Q

Health effects of hypertension

A

Over time can…
-damage blood vessel walls causing scarring that promotes the build-up of fatty plaque
-strains the heart and eventually weakens it (chronic heart failure)
-very high blood pressure can cause blood vessels in the brain to burst resulting in stroke

38
Q

Treatment for Hypertension

A

There are plenty of drugs on the market that effectively lower blood pressure.
However some of them have bad side effects including higher incidence rates of heart attack and stroke, depression, rectile problems, extra urination, weakness in legs, dry hacking cough, skin rash, insomnia.

39
Q

Physical Activity and Hypertension

A

Cumulative evidence from research shows about 30-50% reduction in hypertension with physical activity.

40
Q

Cerebrovascular Disease and Stroke

A

Conditions that develop as a result of problems with the blood vessels that supply the brain.
Also a type of cardiovascular disease that affects the brain’s blood vessels.

41
Q

Mortality of Stroke

A

Stroke is the third leading cause of death in Canada.
6% of all deaths in Canada are due to stroke with cancer and heart disease being first and second.

42
Q

Types of Cerebrovascular Disease

A

Stroke
Transient Ischemic Attack (TIA)
Vascular Dementia

43
Q

Stroke

A

A serious medical condition where the blood supply to the brain is interrupted

44
Q

Transient Ischemic Attach (TIA)

A

A temporary fall in the brain’s blood supply, resulting in a lack of oxygen to the brain.
Often is a sign that stroke is coming

45
Q

Vascular Dementia

A

Problems with the blood circulation, leading to parts of the brain not receiving enough blood and oxygen.

46
Q

Stroke Risk Factors

A

Hypertension
Age
Smoking
Gender
Family History
Diabetes and obesity
CHD
Physical Inactivty

47
Q

Hypertension vs Stroke

A

Primary factor
Men in the Framingham Heart Study who has hypertension were 4 times more likely to have a stroke.
Young adults 5 times higher.

48
Q

Age vs Stroke

A

Stroke risk doubles for each decade after 55.
2/3 of stroke happen in people over 65.

49
Q

Smoking vs Stroke

A

Increases risk of all types.
Leads to arterial damage and atherosclerosis

50
Q

Gender vs Stroke

A

Women have higher stroke risk, are more likely to die from a stroke than men

51
Q

Diabetes and obesity vs Stroke

A

Especially higher for young adults
Risk of stroke is 12 times higher.

52
Q

CHD vs Stroke

A

Atherosclerosis underlies both coronary heart disease and carotid artery disease (plaque reduces blood flow to your brain).

53
Q

Etiology of a Stroke

A

A stroke occurs when a blood clot blocks an artery or a blood vessel breaks, interrupting blood flow to an area of the brain.
When either of these things happen, brain cells begin to die and brain damage occurs.
When brain cells die during a stroke, abilities controlled by that area of the brain are lost (speech, memory, and movement).
Much of the pathophysiology of a stroke involves atherosclerosis (CHD).

54
Q

What is a stroke?

A

When brain loses blood flow to an area and therefore loses oxygen to that area leading to cells being deprived of oxygen and thus dying.

55
Q

What causes a stroke?

A

When blood flow to the brain is cut off most likely due to a clot in an artery.
From blockage (ischemic stroke) or bleed (hemorrhagic).
Blockage is most common.

56
Q

Signs and Symptoms of Stroke

A

Drooping face
Weakness in arms or legs
Difficulty speaking
Changes to vision
Loss of balance
Memory loss

57
Q

Physical Activity and Stroke

A

2008 physical activity guidelines advisory committee:
-moderately active people have a 25-30% reduced chance of stroke including ischemic and hemorrhagic stroke.
Physical activity reduce brain cell damage after a stroke (evidence from animal studies, but no human evidence).

58
Q

What is cancer?

A

Cancer is a disease that starts in our cells.
Genes inside each cell order it to grow, work, reproduce, and die.
Normally, our cells obey these orders but sometimes the instructions get mixed up, causing the cells to form tumours (rapid reproduction of mutated cells) or spread through the bloodstream and lympathetic system to other parts of the body.
Cancers are named after the part of the body where they start.

59
Q

Types of Tumours

A

Benign (non-cancerous)
Malignant (cancerous)

60
Q

Benign Tumours

A

Non-cancerous
Cells stay in one place in the body
Not usually life-threatening

61
Q

Malignant Tumour

A

Cancerous
Cells are able to invade nearby tissues and spread to other parts of the body
Cancer cells that spread to other parts of the body are called metastases
First sign that malignant tumour has spread is often swelling of nearby lymph nodes, but cancer can metastasize to almost any part of the body.
-it is important to find malignant tumours as early as possible

62
Q

Risk Factors for Cancer

A

Different cancers have different risk factors, though some risk factors are associated with several cancers.
Smoking is a risk for cancers of the lung, mouth, throat, larynx, esophagus, pancreas, kidney, bladder, and cervix.
Excessive sun exposure and burning.
Physical inactivity - physical activity moves food through the digestive system faster, less time for harmful substances to be in contact with bowel.
The pathophysiology that leads to specific site cancers is less well understood than for some other chronic diseases such as CVD and type 2 diabetes.

63
Q

Physical Activity and Cancer

A

The earliest epidemiological studies postulating that physical activity may reduce the risk of developing cancer were published in 1922.
Men who worked in physically demanding occupations had lower cancer mortality rates than men in less demanding ones.
Subsequently, there is little research interest in this topic until 80’s and 90’s.
Physical activity reduces the risks of developing colon and breast cancers.
The expert panel also found that the evidence was suggestive for lower risks of lung, endometrial, and ovarian cancers associated with physical activity.