Chronic Diahria In Infants Flashcards

1
Q

State 3 definitions of diahria

A

-increase in number of stool:
N in artificial feeding ( 1 to 3 per day)
N in BF (4 to 6 per day)
-increase in volume or better stool weight collected over 3 days (normally less than 2% of infant weight)
-change in appearance of stools (watery, liquid, greasy, or bloody)

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2
Q

We should eliminate the “false diarrhoea”of chronic constipation
T or f

A

T

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3
Q

What is the definition of chronic diahria

A

> 15 d

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4
Q

In the absence of any consequence for diarrhia we should think of 2 DD:

A

-toddlers diarrhoea / irritable bowel/ functional colopathy
-prandial diarrhea of infants

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5
Q

What is the cause of prandial diarrhoea

A

Physiological cause
These children when ingesting milk go to stool directly (still absorb nutrients but consistency of stool changes)

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6
Q

In functional colopathy there is a dysfunction in colon leading to chronic diahria

A

F, the colon is fully functional

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7
Q

Toddlers diahria is the most frequent cause of chronic diahria in infants aged between 1 to 4y and having bad W and L curve

A

F
They have good W L curve

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8
Q

Why does toddlers diahria develop

A

It develops due to errors in diet (abusive diet)
-Too early introduction of food
-Hypolipidic food
-Hyperprotid food
-Hypercaloric food
-increase in fruit juice (An example of inadvertent nutrient insufficiency is the excessive feeding of fruit juice to young
children)
-sorbitol containing products

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9
Q

Harmful effects of fruit juice

A

-dental carries
-obesity
-malnutrition
-abd pain
-diahria

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10
Q

How can we avoid the harmful effects of fruit juice

A

-not from bottle
-not before 6m
-whole fruit is better
-pastured

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11
Q

State the cases where we have N weight to height curve associated with chronic diahria

A

1) toddlers diahria/ irritable bowel
2) pancreatic insufficiency
3) sugar malabsorption

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12
Q

State the cases where we have abnormal weight to height curve associated with chronic diahria

A

-malabsorption (celiac and APLV and giardia)
-maldigestion
-inflammation

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13
Q

In case of clinical impact of diahria, what organic cause may be present

A

1) Celiac dz and gluten intolerence
2) CF and pancreatic insuff
3) sugar intolerence
4) cows milk allergy
5) inflammation
6) amebiasis

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14
Q

What are the 3 examinations that we should do when a pt arrives with chronic diahria

A

1) evaluate the impact of chronic diahria
2) study the fts of digestion and absorption
3) precise etiological orientation

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15
Q

How can we evaluate the impact of the chronic diahria on pts body

A

-CBC (search for anemia)
-iron
-electrophoresis for proteins ( hypo albunemia/ hypo gammaglobulinemia)
-liposoluble vitamines (A,E, PT for vit K)
-folate
-inflammatory profile
-phosphocalcic profile : alkaline phosphatase, calcemia, radio for bone

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16
Q

What are specific tests that are done to study digestion and absorption of sugars

A

•sugar:
-sugar reductors in stool
-stool ph
-D xylose test for absorption( N: absorbed, indigested, eliminated by urine/ Abn: eliminated by stool)
-resp test
-serum folate

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17
Q

What are specific tests that are done to study digestion and absorption of proteins

A

-creatorrhea
-clearance of alfa 1 antitrypsin
(Anti trypsin is not digested by trypsin, it appears only in case of exudation)

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18
Q

What are specific tests that are done to study digestion and absorption of fats

A

-carotene level
-fat soluble vitamins level, PT (vit k)
-steatirhea

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19
Q

In practice, 95% of chronic diahria in infants are relevent to 5-6 etiologies

A

T

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20
Q

What are the tests that quickly confirms the cause of chronic diahria

A

-stopping cows milk
-sweat test
-biopsy of SI

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21
Q

Diahria by malabsorption includes

A

-ALVP
-celiac dz
-giardiasis

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22
Q

Villous atrophy exists in

A

-APLV
-celiac dz

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23
Q

APLV is the most SEVERE food intolerance of child

A

T

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24
Q

The milk allergy is more severe in young due to

A

-immature digestive phenomena
-infectious attacks of intestinal mucosa
-familial atopy

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25
Clinical picture
-vomiting -diahria -cutaneous signs -malaise
26
Allergy to what protein in milk
Betta globulin
27
Tx of AVLP includes only BF
F 1) BF 2) hypoallergic formula: polypeptide containing formula 3) elementary formula: aa containing formula (neocate)
28
Tx pf AVLP extends for 12 to 15 months with gradual re introduction in hospital
T
29
It is recommended to use soybeans since there is no cross reactivity with PLV
F It is not recommended to use soybeans since there is cross reactivity with PLV
30
Celiac disease
31
What is celiac dz
Immune mediated enteropathy caused by permanent sensitivity to gluten in **genetically susceptible individuals**
32
Always individuals having celiac are symptomatic T or f
F They may be: Symptomatic (GI or extra GI) Asymptomatic
33
In Asymptomatic individuals, celiac dz may be associated with
-IgA deficiency -Diabetes type 1 -turner -down syndrome -1st degree relative -williams disorder
34
Gluten intolerance is defined based on 3 criteria
-**malabsorption synd** after total/subtotal villous atrophy -**healing** of CLINICAL and HX after stopping gluten -**Reappearance** of clinical signs &/ only histological lesions after the reintroduction of gluten in diet
35
If typical, 1&2 criteria are accepted with +ve Ab
T
36
The typical table of celiac dz consists of
-decrease in weight curve after introduction of gluten (6m to 12m) -fatty diahria -abd bloating
37
State the GI (classic manifestations appear at 6 to 24m) of celiac dz
-vomit -chronic or recurrent diahria -constipation -bloating (abd distention) -abd pain -anorexia -FTT/ wt loss -irritability
38
Non GI manifestation of celiac
-short stature -osteoporosis -epilepsy with occ bone calcification -arthritis -dental enamel hyoplasia -delayed puberty -dermarititis herpatiformis -hepatitis -iron deff anemia -stomatitis -gluten ataxia and other neurological disorders
39
Dermatitis herpatiformis is unilateral and pruritic
F Bilateral With severe pruritis
40
Dermatitis herpatiformis is 90% not associated with GI symptoms And indicates 75% villous atrophy
T
41
Malabsorption tests done in case of celiac
-sugar: D xylose and folate -fat: steatorreha, deficiencies in fat soluble vitamins -late bone maturation
42
Screening for celiac is done by doing different types of Ab What are these
-anti endomysial Ab -anti gliadin -anti reticulin -anti transglutaminase
43
HLA studies are not imp in celiac dz
F Both HLA DQ (2 and 8) HLA DQ2: found in 95% of celiac pts HLA DQ8: found in others
44
HLA testing has a high negative predictive value for celiac dz T or f
T
45
How can we confirm celiac dz
-by SI biopsy Total or subtotal atrophy of villi with decrease in villous /crypt ratio OR lyphoplasmocytic infiltration
46
What are the changes that occur under gluten exlusion
-Rapid **restart of growth** -**villous regrowth** in 6 to 12 m -**regression of all clinical signs** with sometimes clinical sensitivity to diet disorder
47
Long term symps specially if No gluten free diet
-digestive cancer (lymphoma of SI and adenocarcinoma) -autoimmune dz (diabetes, thyroditis) with a probable preventive effect of a diet for life
48
Tx for celiac
Gluten free diet Avoid Barley, wheat, rye, oat
49
Giardasis (lambliasis) can give **chronic disruption by malabsorption** with true pseudoceliac
T
50
Dg of giardiasis
-parasitological exam of stool -Ag in stool is more sensitive -duodenal brushing / search for lamblia in the lining of the loops in biopsy
51
Infection of gardia is severe and can be severe in IGA deficiency
T
52
Maldigestion disorders
-pancreatic origin -biliary origin —> no N bile: imp for lipid digestion -disachharide intolerence -intolerence to sugar of active transport (glucose)
53
Disorders of pancreatic origin
-CF -schwachman synd -Janson blizzard synd -dficit pancreatic lipase -deficiency in enterokinase
54
CF is an auto d dz
F Auto R affecting CFTR gene
55
Clinical presentation of CF
-chronic diahria -not able to compensate completely -recurrent infection -thick secretions : thick bile Thick nasal discharge Thick stool ( obstruct SI (ilius)) Thick sweat (hyponatremia) Thick sperm secretion
56
Confirm CF by which test
Sweat test Genetic mutation search
57
N to high fat diet is good in CF to decrease lung infection
T
58
Schawchman synd has pancreatic exocrine insufficiency
T
59
What are other characteristics of schwachman
-recurrent infections -neutropenia other hematological abnormalities (pancytopenia) -Metaphyseal dysostosis (ribs or femoral head) -Dwarfism : Liver - Myocardial fibrosis - Mental retardation - Myelo or lymphoblastic leukemia
60
Janson synd is characterized by replacement of pancreatic cells by fat tissue
T
61
Clinical manifestations of janson
-digestive abn (anal imperforation ) -absence of nasal cartilage -deafness -pancreatic insuff -diabetes
62
Also in pancreatic maldigestion we have Deficiency in pancreatic lipase Deficiency in enterokinase
T
63
In deficiency in pancreatic lipase we can eat lipids
F; we cant eat lipids since stool will appear very fatty mtl shame3
64
What is enterokinase
A digestive enzyme from duo that insure the activation of trypsin (protein problem)
65
Sugar intolerance
66
What are 2 mech of sugar intolerence
- absence of disacharidase that causes lack of hydrolysis of disach—> the most common mechanism Rarely