Chronic cutaneous lupus erythematosus (CCLE) Flashcards
______ accounts for the majority of CCLE.
- Discoid lupus
What percent of discoid lupus patients prgress to SLE?
- 5-20%
- but 40-70% of SLE patients will have discoid lesions
If there is only head involvment of DLE, what percent will progress to SLE?
5% (if diffuse involvement then 20%)
If there is diffuse involvement of DLE, what % of patients will progress to SLE?
20%
What are the triggers/risk factors for CCLE?
- UV radiation is important trigger
- Tobacco smoking is risk factor (stopping may help treat recalcitrant lesions)
- Genetics
What are some of the cells involved in pathogenesis of CCLE?
- Type I interferon with CD4 + Th1 cells and CD8 + recruitment and activation
What are the clinical subtypes of CCLE?
- Discoid LE
- Hypertophic (verrucous) LE
- Chilblain LE
- Tumid LE
- LE panniculitis/profundus
- Discoid lupus/lichen planus overlap
- Mucosal LE
Describe the lesions of discoid lupus:
- start as red macules or plaques–> develop scale, atrophy and scarring w/ central hypopigmentation and periphral hyperpigmentation
What findings can you see on the scale of DLE lesions?
- Langue du chat= carpet “tack-like” spines on undersurface of scale
What are the typical locations DLE lesions present?
- face, scalp, conchal bowl
Childhood DLE has a (higher or lower) chance to progress to SLE?
- higher
Hypertrophic LE is a subtype of CCLE that presents as:
- thick, hyperkeratotic and verrucous scaling plaques w/ indurated border
similar to hypertrophic LP, hypertrophic LE patients have increased risk of ____
SCC
Hypertrophic LE favors (upper/lower half) of the body, while hypertrophic LP favors (upper/lower half)
- Hypertrophic LE upper half
- HLP lower half
Chilblain lupus erythematosus presents as:
- painful, red or dusky purple papules/plaques on fingertips, rims of ears, calves and heels