Antinuclear antibodies Flashcards
Anti Ro/SS most strongly a/w
- Sjogren syndrome (70%)
- neonatal lupus (100%)
- but, can also be seen in SCLE (75%-90%) and SLE (50%)
Anti La/SSB most strongly a/w:
- Sjogren syndrome (40%)
- but also seen in SCLE
Anti SCL-70 is aka:
DNA topoisomerase I
Anti SCL-70 (DNA topoisomerase I) is most strongly a/w:
- diffuse SSc (60%)
Anti Jo-I is a/w:
- Dermatomyositis/polymyositis
Anti smith ab is highly _____ for SLE
- specific (only 30% sensitive)
very high titers of anti RNP antibodies is a/w:
MCTD
anti dsDNA ab is highly specific for ______
SLE
antibody a/w drug induced lupus:
- anti histone
Antibody a/w CREST:
- Anti Centromere (80%)
ANA is considered positive if dilution of ____
> 1:40
- about 20-30% of healthy people have 1:40
What percentage of healthy people have ANAs around 1:40?
20-30%
What percent of SLE patients will have positive ANA:
- 99%
What will lupus band test show in SLE?
- Granular continuous band of IgM>IgG>IgA and C3 at DEJ
Which lupus band test correlates with anti-dsDNA abs and is a/w severe extracutaneous disease including renal?
- Sun-protected, non-lesional skin lupus band test