Antinuclear antibodies Flashcards

1
Q

Anti Ro/SS most strongly a/w

A
  • Sjogren syndrome (70%)
  • neonatal lupus (100%)
  • but, can also be seen in SCLE (75%-90%) and SLE (50%)
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2
Q

Anti La/SSB most strongly a/w:

A
  • Sjogren syndrome (40%)

- but also seen in SCLE

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3
Q

Anti SCL-70 is aka:

A

DNA topoisomerase I

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4
Q

Anti SCL-70 (DNA topoisomerase I) is most strongly a/w:

A
  • diffuse SSc (60%)
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5
Q

Anti Jo-I is a/w:

A
  • Dermatomyositis/polymyositis
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6
Q

Anti smith ab is highly _____ for SLE

A
  • specific (only 30% sensitive)
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7
Q

very high titers of anti RNP antibodies is a/w:

A

MCTD

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8
Q

anti dsDNA ab is highly specific for ______

A

SLE

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9
Q

antibody a/w drug induced lupus:

A
  • anti histone
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10
Q

Antibody a/w CREST:

A
  • Anti Centromere (80%)
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11
Q

ANA is considered positive if dilution of ____

A

> 1:40

- about 20-30% of healthy people have 1:40

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12
Q

What percentage of healthy people have ANAs around 1:40?

A

20-30%

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13
Q

What percent of SLE patients will have positive ANA:

A
  • 99%
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14
Q

What will lupus band test show in SLE?

A
  • Granular continuous band of IgM>IgG>IgA and C3 at DEJ
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15
Q

Which lupus band test correlates with anti-dsDNA abs and is a/w severe extracutaneous disease including renal?

A
  • Sun-protected, non-lesional skin lupus band test
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