Chron’s disease

Question 1

What is Chron’s disease?

Answer 1

Chronic inflammation of the distal ileum and colon but may occur in any part of the GI tract besides the rectum.

Question 2

What two age groups have a higher risk of Chrons Disease?

Answer 2

15 - 30 year olds

60 - 70 year olds

Question 3

What are the causes of Chrons?

Answer 3

- Unknown 
But factors such as:
Genetic, 
microbial, 
immunologic
environmental
dietary
vascular
psychosocial
smoking 
oral contraceptives 
NSAIDs could add to the development of Chrons

Question 4

How does tissue injury develop in Chrons?

Answer 4

Chronic inflammation from T-cell activation

Question 5

What effect does inflammation have on the bowels?

Answer 5

Thickens the bowel wall and narrows the lumen.
As Crohn disease progresses, it is complicated by obstruction or deep ulceration leading to fistulization, abscess formation, adhesions, and malabsorption.

Question 6

What initially causes bowel obstruction in Chrons ?

Answer 6

Caused initially by significant oedema of the mucosa and associated spasm of the bowel.

Question 7

What happens when there is prolonged bowel obstruction?

Answer 7

fibrotic scarring
luminal narrowing
stricture formation

Question 8

What are the two most common signs of Chrons?

Answer 8

Abdominal pain and diarrhoea

Question 9

What are some other signs and Chrons?

Answer 9

Fever
Weight loss, anorexia
Nausea, vomiting
Malnutrition, vitamin deficiencies
Generalized fatigability
Bone loss
Psychological Factors 
Growth failure in adolescent patients