Chromosome mutations Flashcards
What kind of mutation is the notch wing in drosophila?
A deletion mutation
What is the cause of Cri Du Chat syndrome?
A deletion of the tip of chromosome 5 , children die young https://www.youtube.com/watch?v=TYQrzFABQHQ
How can deletions be useful to gene mapping?
In heterozygotes, can result in unexpected phenotypes presenting themselves
How have duplications been important mutations in the history of life?
The genome expanded likely by a series of duplications
What evidence is there that duplications may have driven expansion of genome?
Often find gene families, collections of similar genes on a chromosome that could have arisen from duplicating one gene
What are the two kinds of duplications?
Tandem and reverse
Which type of duplication is most frequent in non-functional DNA?
Reverse
Bar Eye mutation in drosophila is an example of what kind of mutation?
Tandem duplication, of a particular band of the X
What are some strange results from Bar Eyed drosophila crosses?
Some are born double-bar and some with normal eyes?
What is the explanation for aberrant crosses in bar-eyed drosophila?
Mispairing of tandem duplications
What is an important mechanism for increasing short repeats in the genome?
Mispairing of tandem duplications
What human disease is caused by mispairing of tandem duplications?
Huntington’s Disease
Are the number of repeats in the Huntington’s gene greater for men or women?
Men
What structure results from inversion mutations and can be seen under the microscope?
[Poop] Loop
What is the significance of the inversion loop on population genetics?
It suppresses crossing over, mechanical strain is too much and centromeres need to be conserved
