Christy's Cards

Question 1

Isoniazid

Answer 1

Sx:
AG metabolic acidosis (increased lactate)
Seizures within 1 hr of ingestion - refractory
CNS depression
Lactic acidosis

Chronic OD: 
Peripheral neuritis
Optic neuritis
Hepatitis 
Pancreatitis 
Decreased pyridoxine (B6)

Tx:
Pyridoxine gram per gram

Question 2

Hydrocarbons

Answer 2

Viscosity - how thick
Surface tension - a “surface film” - harder to move an object through the surface
Volatility - how easily a substance can vaporize

Most dangerous for aspiration pneumonitis:

• low viscosity
• low surface tension
• high volatility

Question 3

Ergotamines

Answer 3

Mechanism: peripheral vasoconstriction serotoninergic effects

Sx:

• Convulsions - h/a, spasms, miosis, phsychosis, GI
• Gangrene - due to vasoconstriction, decreased peripheral pulse, mottled skin, burning/tingling, tissue necrosis

Question 4

Disulfiram (antabuse)

Answer 4

Sx: flushing, tachycardia, diaphoresis, GI, ataxia, lethargy, seizures, HA, CP

Tx: benzos, antiemetics, IVF

• alcohol + flagyl –> disulfiram-like reaction

Question 5

Vitamins

Answer 5

Fat soluble:

• A, D, E, K
• Stored in fat cells - don’t need to be replenished every day
• E = anticoagulant effects
• D = hypercalcemia, HTN
• A = GI, hair-loss, dizziness

Water soluble: B, C

• B3 (niacin)
• B6 (pyridoxime)
• B9 (folic acid)
• B12 (cobalamins)