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week 53 > Christie > Flashcards

Christie Flashcards

1
Q

35 y.o. lady

A

Leiomyomas

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2
Q

What neoplasm is associated with types 16 and 18 HPV?

A
  • All of the above
    • Cervical Squamous Cell carcinoma
    • Type 1 vulvar squamous cell carcinoma
    • Vaginal intraepithelial neoplasia
    • Cervical Intraepithelial neoplasia
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3
Q

Why is the cervical transformation zone important?

A
  • Site of origin of cervical dysplasia and carcinoma
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4
Q

T or F: Vaginal Squamous cell carcinoma most often represents spread from squamous cell carcinoma in the cervix or vulva

A

True

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5
Q

False about type II vulvar squamous cell carcinoma

A

Associated with HPV

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6
Q

Risk factors of endometrial carcinoma

A
  • Obesity
  • Diabetes
  • Hypertension
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7
Q

Most common type of endometrial carcinoma

A

Endometrial adenocarcinoma

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8
Q

Characteristics of endometriod endometrial carcinoma?

A
  • Inactivation of DNA mismatch repair genes and the PTEN gene
  • associated with estrogen excess and endometrial hyperplasia
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9
Q

Not a characteristic of serous endometrial carcinoma?

A
  • Found in perimenopausal or postmenopausal women
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10
Q

Risk factors for cervical intraepithelial neoplasia and carcinoma

A
  • Early age at first intercourse
  • multiple sex partners
  • persistent infection by high-risk strains of papillomavirus
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11
Q

The cells on your right in the illustration are

A

Koilocytes

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12
Q

Uterine Leiomyosarcoma

A
  • Daignostic histologic features are:
    • cytologic atypia
    • tumor necrosis
    • mitotic activity
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13
Q

False about ovarian tumors

A
  • most are malignant
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14
Q

What is the breast structure enclosed in the square in this picture?

A
  • The terminal duct lobular unit (=TDLU)
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15
Q

What is the importance of the structure enclosed in the square?

A
  • milk production
  • origin of most breast carcinomas
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16
Q

What is the importance of the lesion depicted in this picture?

A
  • most common benign tumor of the female breast
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17
Q

This lesion occured several years after a 60 year-old lady had a mastectomy and developed chronic lymphedema. it is most likely a

A

Angiosarcoma

18
Q

What is the importance of the lesion depicted in this picture?

A
  • most common malignant stromal tumor of the breast
19
Q

A 60-year-old lady developed a eczematous, scaly, red rash around her nipple. The biopsy is shown in the following picture. The lesion is most likely

A

Paget’s Disease of the nipple

20
Q

What is the importance of the breast lesion

A
  • There is DCIS in the ductal system of the breast
  • There can be invasive carcinoma elsewhere in the breast
21
Q

45 y.o. lady

A

Fibrocystic Disease

22
Q

What are the two most typical presentations of breast carcinoma?

A
  • Lump in the breast
  • abnormal mammogram
23
Q

ER-negative, HER2 negative carcinomas have which molecular changes?

A
  • Germline BRCA1 mutations, TP53 mutation, and BRCA1 inactivation
24
Q

What are the main risk factors for developement of breast carcinoma?

A
  • Estrogenic stimulation
  • older age
25
Q

What is the main biologic subgroup of breast carcinoma?

A
  • estrogen receptor (ER)-positive, HER2-negative
26
Q

What biologic subgroups of breast carcinoma progress the fastest?

A
  • ER-negative, HER2-negative
27
Q
A
28
Q

ER-negative, HER2 negative carcinomas have which molecular changes?

A
  • germline BRCA1 muations
  • TP53 mutation
  • BRCA1 inactivation
29
Q

Inhibin

A
  • found in both men and women
30
Q

What is not produced by Sertoli cells?

A
  • Testosterone
31
Q

What enzyme is responsible for the conversion of testosterone to dihydrotestosterone (DHT).

A
  • 5a-reductase
32
Q

In the male, what cell produces testosterone?

A

Leydig cells

33
Q

Sexual differentiation

A
  • 3 types
34
Q

Prostate carcinoma

A
  • Gleason grading is important for providing info about treatment and prognosis
35
Q

Absent in androgen insensitivity disorder?

A
  • Increased levels of androgen receptors
36
Q

71 y.o. man

A

nodular hyperplasia

37
Q

66 y.o. man

A

absence of the basal epithelial layer

38
Q

Penile erection

A
  • Erection is neurovascular
39
Q

Anabolic steroid users

A
  • elevated LH levels
40
Q

False about seminoma

A
  • Resistant to radiation therapy

week 53 (9 decks)

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