Christie Flashcards
35 y.o. lady
Leiomyomas
What neoplasm is associated with types 16 and 18 HPV?
- All of the above
- Cervical Squamous Cell carcinoma
- Type 1 vulvar squamous cell carcinoma
- Vaginal intraepithelial neoplasia
- Cervical Intraepithelial neoplasia
Why is the cervical transformation zone important?
- Site of origin of cervical dysplasia and carcinoma
T or F: Vaginal Squamous cell carcinoma most often represents spread from squamous cell carcinoma in the cervix or vulva
True
False about type II vulvar squamous cell carcinoma
Associated with HPV
Risk factors of endometrial carcinoma
- Obesity
- Diabetes
- Hypertension
Most common type of endometrial carcinoma
Endometrial adenocarcinoma
Characteristics of endometriod endometrial carcinoma?
- Inactivation of DNA mismatch repair genes and the PTEN gene
- associated with estrogen excess and endometrial hyperplasia
Not a characteristic of serous endometrial carcinoma?
- Found in perimenopausal or postmenopausal women
Risk factors for cervical intraepithelial neoplasia and carcinoma
- Early age at first intercourse
- multiple sex partners
- persistent infection by high-risk strains of papillomavirus
The cells on your right in the illustration are
Koilocytes
Uterine Leiomyosarcoma
- Daignostic histologic features are:
- cytologic atypia
- tumor necrosis
- mitotic activity
False about ovarian tumors
- most are malignant
What is the breast structure enclosed in the square in this picture?
- The terminal duct lobular unit (=TDLU)
What is the importance of the structure enclosed in the square?
- milk production
- origin of most breast carcinomas
What is the importance of the lesion depicted in this picture?
- most common benign tumor of the female breast
This lesion occured several years after a 60 year-old lady had a mastectomy and developed chronic lymphedema. it is most likely a
Angiosarcoma
What is the importance of the lesion depicted in this picture?
- most common malignant stromal tumor of the breast
A 60-year-old lady developed a eczematous, scaly, red rash around her nipple. The biopsy is shown in the following picture. The lesion is most likely
Paget’s Disease of the nipple
What is the importance of the breast lesion
- There is DCIS in the ductal system of the breast
- There can be invasive carcinoma elsewhere in the breast
45 y.o. lady
Fibrocystic Disease
What are the two most typical presentations of breast carcinoma?
- Lump in the breast
- abnormal mammogram
ER-negative, HER2 negative carcinomas have which molecular changes?
- Germline BRCA1 mutations, TP53 mutation, and BRCA1 inactivation
What are the main risk factors for developement of breast carcinoma?
- Estrogenic stimulation
- older age
