Christie Flashcards
Triiodothyronine (T3)
- 10% of Thyroid Hormone secretion
- Active Form
What is the active form of Thyroid Hormone
T3
The parafollicular or C cells of the thyroid secrete
Calcitonin
Which of the following statements about T3 and T4 is true
Use transport sytems to cross cell membranes
What reaction does thyroid peroxides catalyze
- oxidation of iodide ion to I2
- organification of I2 into thyroglobulin
- coupling reactions
What inhibits thyroid peroxidase
propylthiouracil
What molecule transports the majority of thyroid hormones in the blood
Thyroid binding globulin
When you suspect hyperthyroidism in a patient, what is the first test you should order.
TSH
What is a effect of thyroid hormone
Increases the basal metabolic rate
Iodide balance in the body
Most of the iodide in the thyroid is stored as thyroglobulin
Thyroid function tests are used for:
- assess overall thyroid status
- evaluate the adequacy of levothyroxine therapy
- monitor the treatment of:
- hyperthyroidism
- hypothyroidism
Not an indication for performing thyroid function testing?
Monitor the treatment of hypothyroidism
What does not inhibit thyroid hormone function?
Increased TBG levels
T or F: “Cold” thyroid nodules are most likely to be neoplastic than are “hot” nodules.
true
Based on your present knowledge, what causes the abnormality shown here
Thyroglossal duct cyst
2 year old child
Thyroxine
What causes the condition seen in this infant?
Hypothyroidism
Goiter
- Plummers syndrome is due to autonomous nodule in a multinodular goiter
In this euthyroid individiual who is otherwise asymptomatic, which of the following is the most likely diagnosis for this lesion?
simple (diffuse) goiter
What are autoimmune diseases?
Graves disease
Hashimoto’s thyroiditis
35 year old lady
Graves Disease
50 year old lady
Hasimotos disease
Thyroid cancer
Cancers metastatic to the thyroid are common
Which of the following neoplasms is most likely to metastasize to the thyroid gland?
renal cell carcinoma
Which of the following thyroid neoplasms has the worst prognosis?
anaplastic carcinoma
Which of the following thyroid carcinomas is most likely to stain for amyloid?
Medullary Carcinoma
Not a feature of multiple endocrine neoplasia?
Same age at diagnosis as sporadic cancers
Which cells secrete PTH.
Chief Cells
What cells form bone
osteoblasts
What is the abnormality shown here
Parathyroid adenoma
40 year old man
Parathyroid adenoma
A lady with lung cancer exhibits the signs and symptoms of hypercalcemia yet here PTH is decreased. What is the cause of her hypercalcemia
Hypercalcemia of malignancy due to PTHrP secretion
What is the most common cause of hypocalcemia in a hospitlized patient?
Decreased serum albumin
Net effect of Vitamin D:
- Increase blood calcium and phosphorus levels
Effect of calcitriol
- Increases calcium and phosphate
T or F: In tertiary hyperparathyroidism, a patient with secondary hyperparathyroidism develops autonomous and excessive parathyroid activity often due to development of an adenoma
True
Which type of MEN would be most likely in an individual with the lesions o fthe tongue shown in this illustration?
MEN 2b
What is secreted by the adrenal gland?
- Cortisol
- Aldosterone
- Catecholamines
- DHEA
What is primarily responsible for production of DHEA
Zona reticularis
45 year old man
Exogenous corticosteroids
19 year old
Neisseria meningitidis
52 year old woman
Autoimmune destruction of the adrenals
45 year old man
increased urinary free catecholamines
Not effect of cortisol?
Decreased breakdown of proteins
Most common cause of Cushing Syndrome?
exogenous/latrogenic corticosteroid administration
Responsible for most symptoms of hyperaldosteronism?
Hypokalemia
T or F: The distinction between metabolic syndrome and cushing syndrome is made on the basis of the anabolic changes produced by Cushing syndrome.
False
