Chpter 18~ 19 `20 Quiz 4 Flashcards

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1
Q

chapter 18~19

Many animal viruses acquire a__________ by budding ?

A. lysogen
B. Alu element
C. cell wall
D. membranous envelope
E. mutant tumor suppressor protein

A

membranous envelope

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2
Q

chapter 18~19

The chain terminatiing group on a ddNTP used in Sanger sequencing is _______ ?

A. 2’-H
B. 5’-phosphate
C. 5’- bisphospate
D. 3’- H
E. 3’- OH

A

3’- H

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3
Q

Chapter 18~19

Tobacco mosaic disease is caused by a _______ agent than other pathogens known at the time ?

A. more virulent
B. larger
C. less hydrophilic
D. smaller
E. less virulent

A

smaller

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4
Q

Chapter 18~19

Explain “Prions” term of three definition

A
  • slow manifesting brain diseases
  • scrapie in sheep, mad cow disease, creutzfeldt-jakob desease.
  • No virion , No viral genome
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5
Q

Chapter 18~19

Antibody response with what disease ?

A
  • Viral diseases
    * New viral diseases
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6
Q

Chapter 18~19

Viral disease and New viral disease define explain

A
  • Viral : small isolated population can emerge
  • New: can emerge when viruses spread from animals to humans
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7
Q

Chapter 18~19

For “vitro sequencing” , use ddNs or ddNTPS ?

A

ddNTPS

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8
Q

Chapter 18~19

For “anti-virals” , use ddNs or ddNTPS ?

A

ddNs

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9
Q

Chapter 18~19

Anti-virals definition

A

Can cross the cell membrane, phosphorylated by intracellular enzymes.

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10
Q

Chapter 18~19

3’- dideoxies definition

A

used for Sanger sequencing

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11
Q

Chapter 18~19

Nucleoside RT ( NRTIs) definition

A

chain terminators becuase of a substitution at the 3’ postion, replacing 3’OH

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12
Q

Chapter 18~19

“Proviral “ definition

A
  • Into to genome
  • provirus resides in the host genome
  • replicates along with chromosomal DNA every S phase.
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13
Q

Chapter 18~19

Rereoviruses

A

use reverse transcriptase to copy their RNA genome into DNA

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14
Q

Chapter 18~19

Proviral DNA

A

integrates into host chromosome ( akin to prophage DNA of temperate

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15
Q

Chapter 18~19

What is HIV1 ?

A

The retrovirus that cause AIDS

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16
Q

Chapter 18~19

The lysogenic cycle

A
  • the genome of a temperate phage replicated without destroying the host cell
  • they into the host chromosome via a circular DNA prophage intermediate
  • have temperate phage
17
Q

Chapter 18~19

The Cytic Cycle

A
  • kill the host ccell
  • produces new phage and lyses( breaks open ) the host cell wall
  • virulent phage
  • bacteria have defenses against phage infection including restriction enzymes.
18
Q

Chapter 18~19

Prophage is integrated viral DNA and what else can respond ?

A
  • can rest dormant as infected host cells propagate
  • copy along with host genome , pass on to daughter cells
19
Q

Chapter 18~19

viral envelopes

A

capsids of influenza viruses and animal

19
Q

Chapter 18~19

temperate phage

A

can progressby two different pathways, lytic and lysogenic

20
Q

Chapter 18~19

Bacteriophages also call phages

A

viruses that infect bacteria

21
Q

Chapter 18~19

the protein sheel that enclosesmthe viral genome

A

capsid

22
Q

Chapter 18~19

Describe two type of variation in influenza virus, which one is more important for developing an effective vaccine and why ?

A

Two type of variation
antigenic drift is can lead to changes in the surface proteins of the virus, HA and NA.

antigenic shift generates viruses with entirely new antigens

antigenic shift is important because can result in a new flu A subtype infecting people for the first time

23
Q

Chapter 18~19

why are the NRTIs developed as HIV 1 antivitals nucleoside analogs while the chain teminators use for sanger sequencing are nucleotide analogs ?

A

NRTI is can inhibit the reverse transcriptase enzyme in HIV-1 replication.

Sanger sequencing are nucleotide analogs that lack a 3’-OH group

24
Q

Chapter 18~19

lytic infection leads to a_____ of progeny virus at completion of an infection cycle ?

A. drift
B. dearth
C. burst
D. explosion
E. death

A

burst

25
Q

Chapter 18~19

temperate phage can progress by two different pathways , which two ?

A

lytic and lysogenic

26
Q

Chapter 18~19

A mail-in Covid-19 test uses what ?

A. microarray analysis
B. westerm blotting for viral DNA
C. RT-PCR
D. amniocentesis or chorionic villus biopsy
E. antibody detection of noodle protein

A

RT-PCR

27
Q

Chapter 18~19

The minimum probe length required for reliable library screening is ________ nt.

A. 4
B. 4 to the 15 th power
C. 1kb, the resolution limit of sanger sequencing
D.15-20
E. 3 0000 0000

A

15-20

28
Q

Chapter 18~19

How do protein kinases figures prominently in both proto-oncogene and tumor suppressor signaling pathways ?

A

protein kinases are “integral components” of both proto-oncogene and tumor suppressor signaling pathways.

it can phosphorylate proteins that promote cell cycle arrest.